Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.48 |
| ▸ | GAA | P10253 | 2/20 | 0.48 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | RAB9A | P51151 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | CA1 | P00915 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.46 |
| ▸ | CA4 | P22748 | 1/20 | 0.46 |
| ▸ | CA9 | Q16790 | 1/20 | 0.46 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.43 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.43 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.43 |
| ▸ | APAF1 | O14727 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8549922 | 0.93 | CASP3 (0.61) | TDP1L3MBTL1CASP3ALDH1A1GAA | |
| SCHEMBL8556103 | 0.82 | TDP1 (0.50) | TDP1L3MBTL1CASP3ALDH1A1GAA | |
| SCHEMBL8556105 | 0.82 | TDP1 (0.50) | TDP1L3MBTL1CASP3ALDH1A1GAA | |
| SCHEMBL8556531 | 0.79 | HTR2A (0.58) | ALDH1A1RAB9ASMN1; SMN2TSHRMAOB | |
| SCHEMBL29724090 | 0.76 | CASP3 (0.86) | TDP1L3MBTL1CASP3ALDH1A1GAA | |
| SCHEMBL1142116 | 0.76 | CASP3 (0.86) | TDP1L3MBTL1CASP3ALDH1A1GAA | |
| SCHEMBL11758524 | 0.75 | TDP1 (0.53) | TDP1L3MBTL1MAPTRAB9ASMN1; SMN2 | |
| SCHEMBL30371663 | 0.73 | TDP1 (0.86) | TDP1L3MBTL1CASP3ALDH1A1GAA | |
| SCHEMBL45050 | 0.73 | TDP1 (0.86) | TDP1L3MBTL1CASP3ALDH1A1GAA | |
| SCHEMBL6122839 | 0.72 | RAB9A (0.50) | TDP1L3MBTL1CASP3MAPTRAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0840725-A1 | AZETIDINONE DERIVATIVES FOR THE TREATMENT OF ATHEROSCLEROSIS | SMITHKLINE BEECHAM PLC (GB) | 1998-05-13 | — | — | EP | disclosed |