Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 9/20 | 0.50 |
| ▸ | TRIM24 | O15164 | 2/20 | 0.36 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.34 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.34 |
| ▸ | CYP11B2 | P19099 | 7/20 | 0.33 |
| ▸ | ADAM17 | P78536 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 4/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.33 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.33 |
| ▸ | CYP19A1 | P11511 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2109207 | 0.85 | ALOX5 (0.49) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL8552201 | 0.80 | ALOX5 (0.52) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL8555746 | 0.78 | ALOX5 (0.54) | ALOX5TRIM24CYP11B2CYP11B1CYP1A2 | |
| SCHEMBL8554039 | 0.78 | ALOX5 (0.51) | ALOX5TRIM24PDE3BPDE3ACYP11B2 | |
| SCHEMBL9088351 | 0.77 | ALOX5 (0.72) | ALOX5TRIM24CYP11B2CYP11B1CYP1A2 | |
| SCHEMBL1445372 | 0.76 | ALOX5 (0.41) | ALOX5TRIM24 | |
| SCHEMBL7608078 | 0.76 | ALOX5 (0.41) | ALOX5TRIM24 | |
| SCHEMBL6454601 | 0.76 | ALOX5 (0.41) | ALOX5TRIM24 | |
| SCHEMBL7607693 | 0.76 | ALOX5 (0.41) | ALOX5TRIM24 | |
| SCHEMBL1445371 | 0.76 | ALOX5 (0.41) | ALOX5TRIM24 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |