Known targets — ChEMBL curated mechanism
ACHEADRA1AADRA1BADRA1DADRA2AADRA2BADRA2CADRB1ADRB2ADRB3APH1AAPH1BCHRM2CHRM3EZH2GRIN2AHTR1AHTR1BHTR1DHTR1FHTR3ANCSTNP2RY12PSEN1PSEN2PSENENSIGMAR1SLC6A2SLC6A3SLC6A4
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM2 known ✓ | P08172 | 1/20 | 0.33 |
| ▸ | CHRM3 known ✓ | P20309 | 1/20 | 0.33 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL8558036 | 0.96 | CHRM2 (0.33) | CHRM2CHRM4CHRM1CHRM3 | |
| Bromide SCHEMBL8556591 | 0.93 | CHRM2 (0.39) | CHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL8558853 | 0.89 | CHRM2 (0.39) | CHRM2CHRM4CHRM1CHRM3 | |
| Bromide SCHEMBL8557420 | 0.79 | CHRM2 (0.36) | CHRM2CHRM4CHRM1CHRM3 | |
| Hydrochloric Acid SCHEMBL9585273 | 0.75 | CHRM2 (0.33) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7983365 | 0.75 | CHRM2 (0.33) | CHRM2CHRM4CHRM1CHRM3 | |
| Bromide SCHEMBL8560555 | 0.73 | CHRM2 (0.42) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9050123 | 0.73 | CHRM2 (0.36) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL7985447 | 0.71 | CHRM2 (0.40) | CHRM2CHRM4CHRM1CHRM3 | |
| SCHEMBL9136497 | 0.71 | CHRM2 (0.46) | CHRM2CHRM4CHRM1CHRM3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0366304-B1 | Heterocyclic derivatives, process for their preparation and pharmaceutical compositions containing them | BEECHAM GROUP PLC (GB) | 1998-04-15 | — | — | EP | disclosed |
| US-5166357-A | Nitrogen heterocylic compounds used in treatment of dementia in mammals | BEECHAM GROUP P.L.C. (GB) | 1992-11-24 | — | — | US | disclosed |