Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.43 |
| ▸ | HPGD | P15428 | 2/20 | 0.43 |
| ▸ | PLK1 | P53350 | 1/20 | 0.42 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | ACACB | O00763 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | TAS1R3 | Q7RTX0 | 1/20 | 0.40 |
| ▸ | TAS1R1 | Q7RTX1 | 1/20 | 0.40 |
| ▸ | OPRD1 | P41143 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.38 |
| ▸ | PDE4A | P27815 | 1/20 | 0.38 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.38 |
| ▸ | NQO2 | P16083 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4485529 | 0.86 | ALDH1A1 (0.59) | ALDH1A1SMN1; SMN2HPGDPLK1EPHX2 | |
| SCHEMBL14840584 | 0.78 | TSHR (0.54) | ALDH1A1SMN1; SMN2LMNACYP2C19TDP1 | |
| SCHEMBL21628616 | 0.77 | ALDH1A1 (0.76) | ALDH1A1SMN1; SMN2HPGDPLK1LMNA | |
| SCHEMBL8248223 | 0.75 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HPGDACACBOPRD1 | |
| SCHEMBL12052087 | 0.75 | ALDH1A1 (0.52) | ALDH1A1SMN1; SMN2HPGDACACBOPRD1 | |
| SCHEMBL13814506 | 0.74 | HDAC8 (0.58) | ALDH1A1SMN1; SMN2HPGDEPHX2NR1H4 | |
| SCHEMBL25356949 | 0.73 | SLC7A5 (0.61) | ALDH1A1SMN1; SMN2LMNAACACBMEN1 | |
| SCHEMBL25356945 | 0.73 | SLC7A5 (0.61) | ALDH1A1SMN1; SMN2LMNAACACBMEN1 | |
| SCHEMBL3818379 | 0.73 | LOXL2 (0.55) | ALDH1A1SMN1; SMN2HPGDEPHX2NR1H4 | |
| SCHEMBL855667 | 0.73 | ALDH1A1 (0.58) | ALDH1A1SMN1; SMN2HPGDPLK1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1308438-B9 | 3-SUBSTITUTED UREA DERIVATIVES AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2012-03-28 | — | — | EP | disclosed |
| EP-1308438-B1 | 3-SUBSTITUTED UREA DERIVATIVES AND MEDICINAL USE THEREOF | MITSUBISHI TANABE PHARMA CORP (JP) | 2010-10-20 | — | — | EP | disclosed |
| US-7105567-B2 | 3-substituted urea derivatives and medicinal use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2006-09-12 | — | — | US | disclosed |
| CN-1231464-C | Novel 3-substituted urea derivatives and pharmaceutical use thereof | MITSUBISHI PHARMACEUTICAL CO L (JP) | 2005-12-14 | — | — | CN | disclosed |
| CN-1466569-A | Novel 3-substituted urea derivatives and pharmaceutical use thereof | ������ҩ��ʽ���� | 2004-01-07 | — | — | CN | disclosed |
| US-20030207939-A1 | Novel 3-substituted urea derivatives and medicinal use thereof | MITSUBISHI PHARMA CORPORATION (JP) | 2003-11-06 | — | — | US | disclosed |
| EP-1308438-A1 | 3-SUBSTITUTED UREA DERIVATIVES AND MEDICINAL USE THEREOF | Mitsubishi Pharma Corporation (JP) | 2003-05-07 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20030207939-A1 | Novel 3-substituted urea derivatives and medicinal use thereof | C5AR1, C5AR2, C3AR1 | ALDH1A1 2416/4885SMN1; SMN2 1060/4885HPGD 3900/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.