Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 2/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | THRB | P10828 | 1/20 | 0.41 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.41 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.40 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.40 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.40 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556535 | 0.85 | AVPR1A (0.52) | AVPR2AVPR1A | |
| SCHEMBL8561675 | 0.85 | NAMPT (0.50) | NAMPTTHRBKCNQ2KCNJ5KCNJ3 | |
| SCHEMBL8820647 | 0.84 | AVPR2 (0.50) | NAMPTTHRBKCNQ2KCNJ5KCNJ3 | |
| SCHEMBL8562567 | 0.81 | AVPR2 (0.48) | AVPR2AVPR1A | |
| SCHEMBL8556396 | 0.81 | AVPR2 (0.55) | AVPR2AVPR1A | |
| SCHEMBL8559368 | 0.78 | AVPR1A (0.59) | AVPR2AVPR1A | |
| SCHEMBL7340964 | 0.77 | KCNJ5 (0.48) | ROCK2THRBKCNQ2KCNJ5KCNJ3 | |
| SCHEMBL8820413 | 0.75 | AVPR2 (0.56) | NAMPTAVPR2AVPR1A | |
| SCHEMBL8318866 | 0.74 | KCNJ5 (0.47) | NAMPTTHRBKCNQ2KCNJ5KCNJ3 | |
| SCHEMBL8313496 | 0.74 | KCNJ5 (0.45) | NAMPTTHRBKCNQ2KCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |