Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NAMPT | P43490 | 1/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.48 |
| ▸ | KCNQ2 | O43526 | 1/20 | 0.47 |
| ▸ | KCNJ5 | P48544 | 1/20 | 0.47 |
| ▸ | KCNJ3 | P48549 | 1/20 | 0.47 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7340964 | 0.90 | KCNJ5 (0.48) | THRBKCNQ2KCNJ5KCNJ3 | |
| SCHEMBL8557382 | 0.88 | AVPR2 (0.50) | NAMPTAVPR1A | |
| SCHEMBL8558667 | 0.85 | NAMPT (0.54) | NAMPTAVPR1AALDH1A1 | |
| SCHEMBL8820647 | 0.85 | AVPR2 (0.50) | NAMPTTHRBKCNQ2KCNJ5KCNJ3 | |
| SCHEMBL8556714 | 0.85 | ROCK2 (0.43) | NAMPTTHRBKCNQ2KCNJ5KCNJ3 | |
| SCHEMBL8563056 | 0.83 | ALDH1A1 (0.48) | NAMPTAVPR1AALDH1A1 | |
| SCHEMBL8564664 | 0.83 | NAMPT (0.47) | NAMPTAVPR1A | |
| SCHEMBL8562670 | 0.82 | AVPR1A (0.60) | AVPR1A | |
| SCHEMBL8556457 | 0.82 | AVPR2 (0.58) | NAMPTAVPR1A | |
| SCHEMBL8559196 | 0.82 | THRB (0.55) | NAMPTTHRBKCNJ5KCNJ3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |