Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.77 |
| ▸ | MEN1 | O00255 | 3/20 | 0.77 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | POLB | P06746 | 1/20 | 0.56 |
| ▸ | G6PD | P11413 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.54 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2317149 | 0.87 | HTT (0.88) | KMT2AMEN1HTTNPC1RAB9A | |
| SCHEMBL1272337 | 0.85 | KMT2A (0.70) | KMT2AMEN1HTTNPC1RAB9A | |
| SCHEMBL9311985 | 0.84 | KMT2A (0.75) | KMT2AMEN1HTTNPC1RAB9A | |
| SCHEMBL13901436 | 0.84 | KMT2A (0.74) | KMT2AMEN1HTTNPC1RAB9A | |
| SCHEMBL8286986 | 0.84 | KMT2A (0.74) | KMT2AMEN1HTTNPC1RAB9A | |
| SCHEMBL18496176 | 0.83 | MEN1 (0.58) | KMT2AMEN1HTTPOLBHDAC1 | |
| SCHEMBL1059736 | 0.82 | KMT2A (0.72) | KMT2AMEN1HTTNPC1RAB9A | |
| SCHEMBL5429131 | 0.81 | RAB9A (0.56) | KMT2AMEN1HTTNPC1RAB9A | |
| SCHEMBL6072206 | 0.81 | KMT2A (0.70) | KMT2AMEN1HTTNPC1RAB9A | |
| SCHEMBL19185049 | 0.81 | MEN1 (0.70) | KMT2AMEN1HTTNPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0623614-B1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LTD (GB) | 1998-02-25 | — | — | EP | disclosed |
| US-5512594-A | ADMINISTERING TO TREAT A MEDICAL CONDITION MEDIATED BY ONE OR MORE LEUKOTRIENES | ZENECA LIMITED (GB) | 1996-04-30 | — | — | US | disclosed |
| US-5478842-A | Antiinflammatory agents, antiallergens, drugs for treatment of diseases mediated by leukotrienes | ZENECA LIMITED (GB) | 1995-12-26 | — | — | US | disclosed |
| WO-1994025453-A1 | 4-ARYL-4-HYDROXY-TETRAHYDROPYRANS AND 3-ARYL-3-HYDROXY-TETRAHYDROFURANS AS 5-LIPOXYGENASE INHIBITORS | ZENECA LIMITED (GB) | 1994-11-10 | — | — | WO | disclosed |
| EP-0623614-A1 | 4-Aryl-4-hydroxy-tetrahydropyrans and 3-aryl-3-hydroxy-tetrahydrofurans as 5-lipoxygenase inhibitors | ZENECA LIMITED (GB) | 1994-11-09 | — | — | EP | disclosed |