Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDK2 | Q15119 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.30 |
| ▸ | PDK3 | Q15120 | 1/20 | 0.30 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557018 | 1.00 | PDK2 (0.33) | PDK2KMT2AMEN1PDK1PDK3 | |
| SCHEMBL8555928 | 0.88 | PDK2 (0.35) | PDK2 | |
| SCHEMBL8557766 | 0.87 | PDK2 (0.32) | PDK2KMT2AMEN1ALDH1A1HTT | |
| SCHEMBL8557765 | 0.87 | PDK2 (0.32) | PDK2KMT2AMEN1ALDH1A1HTT | |
| SCHEMBL8555134 | 0.85 | ALDH1A1 (0.37) | PDK2KMT2AALDH1A1 | |
| SCHEMBL8596431 | 0.84 | KMT2A (0.32) | PDK2KMT2AMEN1ALDH1A1HTT | |
| SCHEMBL8596432 | 0.84 | KMT2A (0.32) | PDK2KMT2AMEN1ALDH1A1HTT | |
| SCHEMBL8554583 | 0.83 | PDE4B (0.37) | ALDH1A1 | |
| SCHEMBL9094152 | 0.79 | KDM4E (0.30) | ALDH1A1 | |
| SCHEMBL9094155 | 0.79 | KDM4E (0.30) | ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |