Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.41 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | HTT | P42858 | 2/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | BRD4 | O60885 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CTSS | P25774 | 1/20 | 0.32 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25153033 | 0.73 | KDM4E (0.44) | KDM4EMAPTLMNAPKMHTT | |
| SCHEMBL11473765 | 0.70 | ALDH1A1 (0.48) | KDM4EMAPTLMNAPKMHTT | |
| SCHEMBL10998016 | 0.70 | ALDH1A1 (0.51) | KDM4EMAPTLMNAPKMHTT | |
| SCHEMBL19327480 | 0.69 | HTT (0.38) | KDM4EMAPTHTTSMN1; SMN2ALDH1A1 | |
| SCHEMBL11487030 | 0.68 | ALDH1A1 (0.41) | KDM4EMAPTLMNAPKMHTT | |
| SCHEMBL10994562 | 0.67 | MET (0.46) | KDM4EMAPTHTTSMN1; SMN2GAA | |
| SCHEMBL10996935 | 0.67 | RXFP1 (0.43) | KDM4EMAPTLMNAHTTSMN1; SMN2 | |
| SCHEMBL14832909 | 0.67 | KDM4E (0.53) | KDM4ESMN1; SMN2ALDH1A1HSD17B10KMT2A | |
| SCHEMBL11626618 | 0.66 | KDM4E (0.49) | KDM4EMAPTLMNAPKMSMN1; SMN2 | |
| SCHEMBL1426882 | 0.65 | KDM4E (1.00) | KDM4EMAPTLMNAPKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20250002507-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | VANDERBILT UNIVERSITY | 2025-01-02 | — | — | US | disclosed |
| WO-2023064584-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | VANDERBILT UNIVERSITY (US) | 2023-04-20 | — | — | WO | disclosed |
| EP-2760866-A1 | DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS | Genfit (FR) | 2014-08-06 | — | — | EP | disclosed |
| WO-2013045519-A1 | DERIVATIVES OF 6-SUBSTITUTED TRIAZOLOPYRIDAZINES AS REV-ERB AGONISTS | GENFIT (FR) | 2013-04-04 | — | — | WO | disclosed |
| EP-0620224-B1 | Triazolopyridazine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES LTD (JP) | 1998-07-15 | — | — | EP | disclosed |
| US-5492909-A | ANTI-PLATELET ACTIVATING FACTOR, ANTIALLERGEN, ANTIASTHMATIC | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1996-02-20 | — | — | US | disclosed |
| EP-0620224-A1 | Triazolopyridazine derivatives, their production and use | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1994-10-19 | — | — | EP | disclosed |
| US-4526890-A | Respiratory system disorders | THE DOW CHEMICAL COMPANY (US) | 1985-07-02 | — | — | US | disclosed |
| EP-0029130-A1 | 3,6,7,8-Substituted-s-triazolo(4,3-b)-pyridazines, their preparation and compositions comprising them | THE DOW CHEMICAL COMPANY (US) | 1981-05-27 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20250002507-A1 | 7,8-DIHYDRO-5H-1,6-NAPHTHYRIDINE DERIVATIVES AS POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 FOR TREATING NEUROLOGICAL AND PSYCHIATRIC DISORDERS | CHRM4, CHRM1, CHRM2 | KDM4E 2148/4885MAPT 2346/4885LMNA 3521/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.