Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 4/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.41 |
| ▸ | CTSG | P08311 | 2/20 | 0.40 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | HTT | P42858 | 2/20 | 0.39 |
| ▸ | RGS12 | O14924 | 1/20 | 0.39 |
| ▸ | USP2 | O75604 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | RECQL | P46063 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.37 |
| ▸ | F2 | P00734 | 1/20 | 0.36 |
| ▸ | PLG | P00747 | 1/20 | 0.36 |
| ▸ | CMA1 | P23946 | 1/20 | 0.36 |
| ▸ | CTRC | Q99895 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553469 | 0.93 | ELANE (0.49) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL8558518 | 0.92 | ELANE (0.48) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL8556687 | 0.82 | ELANE (0.56) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL8960950 | 0.79 | PRKCI (0.37) | ELANECTSGLMNAALDH1A1GAA | |
| SCHEMBL8555587 | 0.75 | ELANE (0.54) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL8960633 | 0.71 | TYR (0.37) | ELANECTSGTDP1MEN1KMT2A | |
| SCHEMBL23580135 | 0.70 | ELANE (0.61) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL29882726 | 0.69 | ELANE (0.59) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL23580631 | 0.69 | ELANE (0.59) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL8555608 | 0.67 | ELANE (0.46) | ELANENPSR1CTSGPRTN3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| US-5510366-A | INOTROPIC, ANTIARRHYMTHMIA AGENTS, VASODILATORS | KOWA CO., LTD. (JP) | 1996-04-23 | — | — | US | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |