Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 5/20 | 0.48 |
| ▸ | BID | P55957 | 3/20 | 0.39 |
| ▸ | MCL1 | Q07820 | 3/20 | 0.39 |
| ▸ | BCL2L1 | Q07817 | 2/20 | 0.39 |
| ▸ | BAK1 | Q16611 | 2/20 | 0.39 |
| ▸ | KAT8 | Q9H7Z6 | 2/20 | 0.39 |
| ▸ | PPARG | P37231 | 1/20 | 0.39 |
| ▸ | PPARA | Q07869 | 1/20 | 0.39 |
| ▸ | EP300 | Q09472 | 1/20 | 0.39 |
| ▸ | KAT2A | Q92830 | 1/20 | 0.39 |
| ▸ | KAT2B | Q92831 | 1/20 | 0.39 |
| ▸ | KAT5 | Q92993 | 1/20 | 0.39 |
| ▸ | SAE1 | Q9UBE0 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | CTSG | P08311 | 3/20 | 0.38 |
| ▸ | PRTN3 | P24158 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.37 |
| ▸ | RGS12 | O14924 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8553469 | 0.97 | ELANE (0.49) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL8557250 | 0.92 | ELANE (0.51) | ELANEMCL1NPSR1CTSGPRTN3 | |
| SCHEMBL8960633 | 0.81 | TYR (0.37) | ELANEBIDMCL1BCL2L1BAK1 | |
| SCHEMBL8556687 | 0.79 | ELANE (0.56) | ELANEMCL1EP300NPSR1CTSG | |
| SCHEMBL8555587 | 0.72 | ELANE (0.54) | ELANEMCL1EP300NPSR1CTSG | |
| SCHEMBL8960950 | 0.71 | PRKCI (0.37) | ELANEEP300CTSGLMNAALDH1A1 | |
| SCHEMBL23580135 | 0.67 | ELANE (0.61) | ELANENPSR1CTSGPRTN3TDP1 | |
| SCHEMBL16281890 | 0.67 | EGLN1 (0.60) | MEN1KMT2ALMNAHTT | |
| SCHEMBL8559099 | 0.66 | TYR (0.44) | ELANEBIDMCL1BCL2L1BAK1 | |
| SCHEMBL23580631 | 0.66 | ELANE (0.59) | ELANENPSR1CTSGPRTN3TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0653426-B1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA CO (JP) | 1998-07-22 | — | — | EP | disclosed |
| EP-0653426-A1 | Indole derivatives, salts thereof and heart affection therapeutic agent comprising the same | KOWA COMPANY, LTD. (JP) | 1995-05-17 | — | — | EP | disclosed |