SCHEMBL8557675

SCHEMBL8557675

CC(C)(C)OC(=O)COc1ccc(C(O)CNC(=O)c2cc3c(s2)CCN(C(=O)OC(C)(C)C)C3)nc1

nearest known ligand 0.45

Predicted protein targets (top 7)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 18/20 0.45
WDR77 Q9BQA1 18/20 0.45
HDAC6 Q9UBN7 1/20 0.41
F2 P00734 1/20 0.39
TPSAB1 Q15661 1/20 0.39
TPSD1 Q9BZJ3 1/20 0.39
TPSG1 Q9NRR2 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8555620 0.85 ITGB3 (0.55) PRMT5WDR77HDAC6F2TPSAB1
SCHEMBL8314351 0.83 PRMT5 (0.49) PRMT5WDR77HDAC6F2TPSAB1
SCHEMBL8558884 0.82 ITGB3 (0.53) PRMT5WDR77HDAC6F2TPSAB1
SCHEMBL8556028 0.78 PRMT5 (0.43) PRMT5WDR77HDAC6F2TPSAB1
SCHEMBL8318234 0.77 PRMT5 (0.48) PRMT5WDR77HDAC6
SCHEMBL8560838 0.77 PRMT5 (0.46) PRMT5WDR77HDAC6
SCHEMBL8555276 0.76 MAPT (0.42) PRMT5WDR77HDAC6F2TPSAB1
SCHEMBL8558878 0.76 TPSAB1 (0.46) PRMT5WDR77HDAC6F2TPSAB1
SCHEMBL8455279 0.76 ITGB3 (0.60) PRMT5WDR77HDAC6F2TPSAB1
SCHEMBL8832972 0.76 ITGB3 (0.47) PRMT5WDR77HDAC6F2TPSAB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0641770-B1 NOVEL COMPOUND WITH PLATELET AGGREGATION INHIBITOR ACTIVITY MEIJI SEIKA CO (JP) 1998-05-13 EP disclosed
US-5594004-A CARDIOVASCULAR DISORDERS AND ANTICOAGULANTS MEIJI SEIKA KABUSHIKI KAISHA (JP) 1997-01-14 US disclosed
EP-0641770-A1 NOVEL COMPOUND WITH PLATELET AGGREGATION INHIBITOR ACTIVITY MEIJI SEIKA KABUSHIKI KAISHA (JP) 1995-03-08 EP disclosed