Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.37 |
| ▸ | TUBB1 | Q9H4B7 | 4/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | STAT3 | P40763 | 1/20 | 0.32 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.32 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
| ▸ | CES2 | O00748 | 1/20 | 0.32 |
| ▸ | CES1 | P23141 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557771 | 1.00 | TRPA1 (0.37) | TRPA1TUBB1PTGESALOX5PTGS1 | |
| SCHEMBL6195528 | 0.87 | MAPT (0.43) | TRPA1TUBB1PTGESALOX5PTGS1 | |
| SCHEMBL6195524 | 0.87 | MAPT (0.43) | TRPA1TUBB1PTGESALOX5PTGS1 | |
| SCHEMBL6785139 | 0.83 | TRPA1 (0.46) | TRPA1PTGS1MAPTMEN1KMT2A | |
| SCHEMBL7968227 | 0.77 | TRPA1 (0.42) | TRPA1TUBB1MAPTCYP1A2CYP2C9 | |
| SCHEMBL6201444 | 0.77 | TRPA1 (0.42) | TRPA1TUBB1MAPTCYP1A2CYP2C9 | |
| SCHEMBL6198079 | 0.73 | MAPT (0.44) | MAPTMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL6198084 | 0.73 | MAPT (0.44) | MAPTMEN1KMT2ALMNACYP1A2 | |
| SCHEMBL4775073 | 0.72 | ATM (0.39) | MEN1KMT2ACYP2C9CYP2C19 | |
| SCHEMBL6196704 | 0.72 | MAPT (0.39) | TRPA1TUBB1MAPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0790826-A4 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMA CORP (US) | 1998-11-11 | — | — | EP | disclosed |
| EP-0790826-A1 | DIHYDROPYRIMIDINES AND USES THEREOF | SYNAPTIC PHARMACEUTICAL CORPORATION (US) | 1997-08-27 | — | — | EP | disclosed |