Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPA1 | O75762 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
| ▸ | GLA | P06280 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
| ▸ | GPR35 | Q9HC97 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.38 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.38 |
| ▸ | CES2 | O00748 | 1/20 | 0.38 |
| ▸ | CES1 | P23141 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | GLO1 | Q04760 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6201444 | 1.00 | TRPA1 (0.42) | TRPA1ALDH1A1TDP1GLAPOLB | |
| SCHEMBL6648396 | 0.90 | KDM4E (0.48) | TRPA1ALDH1A1TDP1GLAPOLB | |
| SCHEMBL6683857 | 0.82 | ALDH1A1 (0.47) | TRPA1ALDH1A1TDP1GLAPOLB | |
| SCHEMBL2570880 | 0.81 | AKR1C3 (0.53) | TRPA1CES2CES1TUBB1EGFR | |
| SCHEMBL2570881 | 0.81 | AKR1C3 (0.53) | TRPA1CES2CES1TUBB1EGFR | |
| SCHEMBL6785139 | 0.81 | TRPA1 (0.46) | TRPA1GPR35HTTCYP1A2CYP2C9 | |
| SCHEMBL6194337 | 0.81 | MAPT (0.47) | TRPA1TDP1GAAMAPTTUBB1 | |
| SCHEMBL6194338 | 0.81 | MAPT (0.47) | TRPA1TDP1GAAMAPTTUBB1 | |
| SCHEMBL8557774 | 0.77 | TRPA1 (0.37) | TRPA1CYP1A2CYP2C9CYP2C19CES2 | |
| SCHEMBL8557771 | 0.77 | TRPA1 (0.37) | TRPA1CYP1A2CYP2C9CYP2C19CES2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6268369-B1 | ALPHA SUB 1 INHIBITORS | SYNAPTIC PHARMACEUTICAL CORPORATION | 2001-07-31 | — | — | US | disclosed |