Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.52 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.52 |
| ▸ | APEX1 | P27695 | 1/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.52 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.52 |
| ▸ | HTR7 | P34969 | 1/20 | 0.51 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.51 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.51 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.51 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.51 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.51 |
| ▸ | ADRA1B | P35368 | 1/20 | 0.51 |
| ▸ | HTR1D | P28221 | 6/20 | 0.50 |
| ▸ | HTR1B | P28222 | 5/20 | 0.50 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.50 |
| ▸ | DRD2 | P14416 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8554833 | 0.97 | HTR7 (0.54) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL8557793 | 0.92 | KDM4E (0.59) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL8559489 | 0.91 | HTR1A (0.60) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8558340 | 0.91 | HTR1A (0.60) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8559491 | 0.90 | HTR1A (0.61) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8554831 | 0.89 | HTR7 (0.61) | KDM4EALOX15APEX1KMT2AHSD17B10 | |
| SCHEMBL8557415 | 0.89 | HTR1A (0.64) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8555729 | 0.89 | HTR1A (0.64) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8557416 | 0.88 | HTR1A (0.65) | HTR7ADRA2AADRA2BADRA2CADRA1D | |
| SCHEMBL8560920 | 0.88 | HTR7 (0.65) | KDM4EALOX15APEX1KMT2AHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0683166-B1 | 3-Indolylpiperidines | MERCK PATENT GMBH (DE) | 1998-10-28 | — | — | EP | disclosed |
| EP-0683166-A1 | 3-Indolylpiperidines | MERCK PATENT GmbH (DE) | 1995-11-22 | — | — | EP | disclosed |