Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS1 | P23219 | 15/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 14/20 | 0.38 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KDM6B | O15054 | 1/20 | 0.36 |
| ▸ | KDM4A | O75164 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | KDM4D | Q6B0I6 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11594018 | 0.76 | CA12 (0.40) | PTGS1KDM4EALDH1A1GLAGAA | |
| SCHEMBL18857498 | 0.76 | GAA (0.42) | PTGS1KDM4EALDH1A1GLAGAA | |
| SCHEMBL8557169 | 0.73 | HDAC1 (0.44) | PTGS1ALDH1A1GAAPTGS2KDM4C | |
| SCHEMBL18854020 | 0.70 | CA12 (0.41) | PTGS1KDM4EALDH1A1GLAGAA | |
| SCHEMBL9256324 | 0.68 | BRS3 (0.40) | KDM4EALDH1A1GLAGAAMEN1 | |
| Toluene SCHEMBL28023301 | 0.68 | PTGS1 (0.43) | PTGS1PTGS2 | |
| SCHEMBL9017891 | 0.67 | HDAC1 (0.49) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL15432248 | 0.67 | KDM4E (0.51) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL31146203 | 0.66 | KDM4E (0.47) | KDM4EALDH1A1GLAGAAMEN1 | |
| SCHEMBL14357917 | 0.66 | HDAC1 (0.46) | KDM4EALDH1A1GLAGAAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |