Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.44 |
| ▸ | HDAC3 | O15379 | 3/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 3/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 7/20 | 0.42 |
| ▸ | PTGS2 | P35354 | 6/20 | 0.40 |
| ▸ | KDM4C | Q9H3R0 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | AOC1 | P19801 | 1/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556962 | 0.82 | HDAC3 (0.45) | HDAC1HDAC3HDAC2PTGS1PTGS2 | |
| SCHEMBL8557857 | 0.73 | PTGS1 (0.39) | PTGS1PTGS2KDM4CALDH1A1GAA | |
| SCHEMBL11594018 | 0.73 | CA12 (0.40) | HDAC1HDAC3HDAC2PTGS1PTGS2 | |
| SCHEMBL18857498 | 0.72 | GAA (0.42) | PTGS1PTGS2KDM4CALDH1A1GAA | |
| SCHEMBL9259585 | 0.70 | BRS3 (0.45) | HDAC1HDAC3HDAC2ALDH1A1NPSR1 | |
| SCHEMBL28564192 | 0.68 | AOC1 (0.62) | PTGS1PTGS2GAAAOC1AOC3 | |
| SCHEMBL5279626 | 0.68 | HDAC3 (0.43) | HDAC1HDAC3HDAC2KDM4CALDH1A1 | |
| SCHEMBL18854020 | 0.67 | CA12 (0.41) | PTGS1PTGS2KDM4CALDH1A1GAA | |
| SCHEMBL28577780 | 0.67 | AOC1 (0.61) | PTGS1PTGS2GAAAOC1AOC3 | |
| Hydrochloric Acid SCHEMBL9042761 | 0.67 | HDAC3 (0.42) | HDAC1HDAC3HDAC2KDM4CALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |