Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 7/20 | 0.48 |
| ▸ | HTT | P42858 | 6/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.48 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | TSHR | P16473 | 3/20 | 0.46 |
| ▸ | MEN1 | O00255 | 5/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.45 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.45 |
| ▸ | TP53 | P04637 | 2/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.45 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | POLB | P06746 | 1/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.42 |
| ▸ | PRKCG | P05129 | 2/20 | 0.42 |
| ▸ | PRKCB | P05771 | 2/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.42 |
| ▸ | PRKCA | P17252 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8563545 | 0.83 | CYP2C19 (0.54) | RECQLLMNAHTTSMN1; SMN2CA12 | |
| SCHEMBL4068334 | 0.79 | RECQL (0.66) | RECQLLMNAHTTSMN1; SMN2CA12 | |
| SCHEMBL8596415 | 0.79 | ALDH1A1 (0.51) | RECQLLMNAHTTSMN1; SMN2CA12 | |
| SCHEMBL14572311 | 0.78 | RECQL (0.68) | RECQLLMNAHTTSMN1; SMN2CA12 | |
| SCHEMBL27855398 | 0.78 | RECQL (0.68) | RECQLLMNAHTTSMN1; SMN2CA12 | |
| SCHEMBL17774565 | 0.75 | RECQL (0.54) | RECQLLMNAHTTSMN1; SMN2CA12 | |
| SCHEMBL8596230 | 0.75 | RECQL (0.41) | RECQLLMNAHTTSMN1; SMN2CA12 | |
| SCHEMBL7324890 | 0.75 | CYP3A4 (0.71) | RECQLLMNASMN1; SMN2TSHRMEN1 | |
| SCHEMBL6618815 | 0.75 | CA12 (0.47) | LMNAHTTSMN1; SMN2CA12CA9 | |
| SCHEMBL14310700 | 0.75 | NAMPT (0.54) | RECQLLMNAHTTSMN1; SMN2CA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |