Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C19 | P33261 | 4/20 | 0.54 |
| ▸ | CYP3A4 | P08684 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.54 |
| ▸ | MEN1 | O00255 | 2/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.54 |
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
| ▸ | HTT | P42858 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.47 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.47 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.47 |
| ▸ | CSNK1G2 | P78368 | 1/20 | 0.47 |
| ▸ | CSNK1G1 | Q9HCP0 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 5/20 | 0.47 |
| ▸ | CA12 | O43570 | 2/20 | 0.47 |
| ▸ | CA9 | Q16790 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13971307 | 0.83 | CSNK1A1 (0.46) | CYP3A4HTTSMN1; SMN2CSNK1A1CSNK1D | |
| SCHEMBL8557942 | 0.83 | RECQL (0.49) | CYP2C19CYP3A4TSHRCYP1A2MEN1 | |
| SCHEMBL31014182 | 0.79 | CYP3A4 (0.72) | CYP2C19CYP3A4TSHRCYP1A2MEN1 | |
| SCHEMBL8596415 | 0.79 | ALDH1A1 (0.51) | CYP2C19CYP3A4TSHRCYP1A2MEN1 | |
| SCHEMBL8927387 | 0.78 | ALDH1A1 (0.68) | CYP2C19CYP3A4TSHRTDP1HTT | |
| SCHEMBL197333 | 0.75 | GAA (0.68) | CYP2C19CYP3A4TSHRCYP1A2MEN1 | |
| SCHEMBL197721 | 0.75 | GAA (0.68) | CYP2C19CYP3A4TSHRCYP1A2MEN1 | |
| SCHEMBL20269565 | 0.75 | GBA1 (0.40) | HTTCSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| SCHEMBL20269564 | 0.75 | GBA1 (0.40) | HTTCSNK1A1CSNK1DCSNK1ECSNK1G2 | |
| SCHEMBL7324890 | 0.75 | CYP3A4 (0.71) | CYP2C19CYP3A4TSHRCYP1A2MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618209-B1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR (FR) | 1998-12-23 | — | — | EP | disclosed |
| US-5459138-A | Dysfunctions of glutamatergic neurotransmission associated with learning and memory | ADIR ET COMPAGNIE (FR) | 1995-10-17 | — | — | US | disclosed |
| EP-0618209-A1 | Pyridothiadiazines, processes for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 1994-10-05 | — | — | EP | disclosed |