Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NOS2 | P35228 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 7/20 | 0.41 |
| ▸ | HTT | P42858 | 5/20 | 0.40 |
| ▸ | LMNA | P02545 | 5/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | MITF | O75030 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.38 |
| ▸ | NPY1R | P25929 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.37 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.37 |
| ▸ | MGMT | P16455 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27766587 | 0.91 | HTT (0.44) | NOS2MAPTHTTLMNAKMT2A | |
| SCHEMBL8601080 | 0.89 | HTT (0.43) | NOS2MAPTHTTLMNAKMT2A | |
| SCHEMBL5145767 | 0.88 | MAPT (0.47) | NOS2MAPTHTTLMNAKMT2A | |
| SCHEMBL9987621 | 0.84 | HTT (0.40) | MAPTHTTLMNAKMT2AKDM4E | |
| SCHEMBL8565117 | 0.83 | MAPT (0.39) | MAPTHTTLMNAKMT2AMEN1 | |
| SCHEMBL16919118 | 0.81 | HTT (0.51) | MAPTHTTLMNAKMT2AMEN1 | |
| SCHEMBL16919103 | 0.80 | GFER (0.41) | MAPTHTTLMNAKDM4EMITF | |
| SCHEMBL9995175 | 0.80 | HTT (0.42) | MAPTHTTLMNAKMT2AKDM4E | |
| SCHEMBL8598075 | 0.80 | HTT (0.42) | MAPTHTTLMNAKMT2AKDM4E | |
| SCHEMBL16919121 | 0.80 | ALDH1A1 (0.36) | NOS2MAPTHTTLMNAKMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0598702-B1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | EISAI CO LTD (JP) | 1998-06-10 | — | — | EP | disclosed |
| EP-0628557-B1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | EISAI CO LTD (JP) | 1997-05-02 | — | — | EP | disclosed |
| US-5506238-A | HYPOTENSIVE AGENT | EISAI CO., LTD. (JP) | 1996-04-09 | — | — | US | disclosed |
| EP-0628557-A1 | Biphenylmethane derivatives, the use of them and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-12-14 | — | — | EP | disclosed |
| US-5328911-A | Cardiovascular disorders, hypotensive agents and congestive heart failure | EISAI CO., LTD. (JP) | 1994-07-12 | — | — | US | disclosed |
| CN-1025331-C | Biphenylmethane derivative and pharmacological use | EISAI CO LTD (JP) | 1994-07-06 | — | — | CN | disclosed |
| EP-0598702-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1994-05-25 | — | — | EP | disclosed |
| US-5298518-A | Biphenylmethane derivative and pharmacological use | EISAI CO., LTD. (JP) | 1994-03-29 | — | — | US | disclosed |
| CN-1050539-A | Diphenyl methane derivative and medicinal | EISAI CO LTD (JP) | 1991-04-10 | — | — | CN | disclosed |
| EP-0420237-A1 | Biphenylmethane derivative, the use of it and pharmacological compositions containing same | Eisai Co., Ltd. (JP) | 1991-04-03 | — | — | EP | disclosed |