Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 4/20 | 0.49 |
| ▸ | HTR2B | P41595 | 4/20 | 0.49 |
| ▸ | DRD3 | P35462 | 5/20 | 0.42 |
| ▸ | DRD4 | P21917 | 4/20 | 0.42 |
| ▸ | DRD2 | P14416 | 2/20 | 0.42 |
| ▸ | DRD1 | P21728 | 2/20 | 0.42 |
| ▸ | DRD5 | P21918 | 2/20 | 0.42 |
| ▸ | AADAT | Q8N5Z0 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | HTR1A | P08908 | 3/20 | 0.40 |
| ▸ | HTR2A | P28223 | 3/20 | 0.40 |
| ▸ | HTR1D | P28221 | 2/20 | 0.40 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14852694 | 0.81 | HTR2C (0.50) | HTR2CHTR2BDRD3DRD4DRD2 | |
| SCHEMBL24316035 | 0.78 | HTR2C (0.44) | HTR2CHTR2BDRD3DRD4DRD2 | |
| SCHEMBL8554742 | 0.76 | ALOX12 (0.66) | HTR2CHTR2BDRD3DRD4DRD2 | |
| SCHEMBL9928159 | 0.74 | DRD2 (0.53) | HTR2CHTR2BDRD3DRD4DRD2 | |
| SCHEMBL7257911 | 0.73 | NOTUM (0.51) | HTR2CHTR2BDRD3DRD4DRD2 | |
| SCHEMBL12905306 | 0.71 | DRD3 (0.50) | HTR2CHTR2BDRD3DRD4DRD2 | |
| SCHEMBL31139409 | 0.70 | MEN1 (0.46) | GAAMEN1KMT2AALDH1A1 | |
| SCHEMBL27010072 | 0.70 | DRD2 (0.49) | HTR2CHTR2BDRD3DRD4DRD2 | |
| Hydrochloric Acid SCHEMBL22370080 | 0.69 | HTR2C (0.40) | HTR2CHTR2BGAAMEN1KMT2A | |
| SCHEMBL13068144 | 0.68 | DRD2 (0.51) | DRD3DRD4DRD2DRD1DRD5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0529452-B1 | 1,7-Condensed 3-(piperazinoalkyl)indol derivatives, process and intermediates for their preparation and pharmaceutical compositions containing them | SOLVAY PHARM GMBH (DE) | 1998-11-11 | — | — | EP | disclosed |