⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4783642 | 0.70 | — | — | |
| SCHEMBL19152545 | 0.67 | SLC40A1 (0.31) | — | |
| SCHEMBL7483794 | 0.63 | — | — | |
| SCHEMBL5894796 | 0.63 | — | — | |
| SCHEMBL8800674 | 0.62 | — | — | |
| SCHEMBL11881835 | 0.62 | — | — | |
| SCHEMBL561521 | 0.61 | ATIC (0.39) | — | |
| SCHEMBL1622952 | 0.51 | — | — | |
| SCHEMBL6322598 | 0.48 | — | — | |
| SCHEMBL30979833 | 0.48 | GSK3A (0.92) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-119330909-A | Protein tyrosine phosphatase inhibitors | 上海齐鲁制药研究中心有限公司 | 2025-01-21 | — | — | CN | disclosed |
| CN-118480013-A | Benzo-polycyclic PTPN2 inhibitors based on 1,2, 5-thiadiazolin-3-one structure and uses thereof | 杭州中美华东制药有限公司 | 2024-08-13 | — | — | CN | disclosed |
| EP-0793494-A4 | 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP INC (US) | 1998-01-28 | — | — | EP | disclosed |
| EP-0793494-A1 | 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1997-09-10 | — | — | EP | disclosed |
| WO-1996016649-A1 | 2-HETEROCYCLYLOXY AND THIOMETHYL-1,2,5-THIADIAZOLIDIN-3-ONE 1,1-DIOXIDES AND COMPOSITIONS AND METHOD OF USE THEREOF | SANOFI WINTHROP, INC. (US) | 1996-06-06 | — | — | WO | disclosed |
| EP-0552462-A1 | Thiadiazinecarboxamides, process for their preparation and pharmaceuticals | LUITPOLD PHARMA GmbH (DE) | 1993-07-28 | — | — | EP | disclosed |
| WO-1993012119-A1 | THIADIAZINE CARBOXYLIC ACID AMIDE DERIVATIVES, METHODS OF PREPARING THEM AND DRUGS CONTAINING THEM | LUITPOLD PHARMA GMBH (DE) | 1993-06-24 | — | — | WO | disclosed |