Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.71 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.46 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.46 |
| ▸ | SIGMAR1 | Q99720 | 3/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | CXCR4 | P61073 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL491983 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| SCHEMBL8553937 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| SCHEMBL5839696 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| SCHEMBL491616 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| SCHEMBL21799578 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| SCHEMBL7230416 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| Hydrazine SCHEMBL8556857 | 0.98 | HRH3 (0.67) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| SCHEMBL21799504 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| SCHEMBL21799790 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT | |
| SCHEMBL9322416 | 0.98 | HRH3 (0.75) | HRH3SMN1; SMN2KEAP1SIGMAR1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575954-B1 | Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase acitivity inhibitors and relative preparation process | MEDIOLANUM FARMACEUTICI SRL (IT) | 1998-09-02 | — | — | EP | disclosed |