Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4D | Q08499 | 16/20 | 0.49 |
| ▸ | PDE4A | P27815 | 4/20 | 0.37 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.37 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.37 |
| ▸ | GCK | P35557 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL70307 | 0.88 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL8558466 | 0.84 | PDE4D (0.50) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7356087 | 0.83 | PDE4B (0.48) | PDE4DPDE4APDE4BPDE4CGCK | |
| SCHEMBL7356316 | 0.78 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6858726 | 0.71 | PDE4D (0.60) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7340773 | 0.70 | PDE4D (0.76) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7390353 | 0.69 | PDE4D (0.51) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7357327 | 0.69 | PDE4D (0.56) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL6858838 | 0.68 | PDE4D (0.81) | PDE4DPDE4APDE4BPDE4C | |
| SCHEMBL7356090 | 0.67 | PDE4D (0.49) | PDE4DPDE4APDE4BPDE4C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | claimed |
| EP-0741707-B1 | SUBSTITUTED AROMATIC COMPOUNDS AS c.AMP PHOSPHODIESTERASE- AND TNF-INHIBITORS | RHONE POULENC RORER LTD (GB) | 1998-04-01 | — | — | EP | disclosed |