Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.51 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | DHFR | P00374 | 4/20 | 0.49 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.48 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.47 |
| ▸ | SIRT1 | Q96EB6 | 1/20 | 0.47 |
| ▸ | SIRT3 | Q9NTG7 | 1/20 | 0.47 |
| ▸ | IFNAR1 | P17181 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | PDE7A | Q13946 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | NPY1R | P25929 | 1/20 | 0.42 |
| ▸ | NPY2R | P49146 | 1/20 | 0.42 |
| ▸ | HTR6 | P50406 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2890325 | 0.84 | IFNAR1 (0.49) | HPGDDHFRCYP3A4TSHRMAPK1 | |
| SCHEMBL31490493 | 0.84 | IFNAR1 (0.49) | HPGDDHFRCYP3A4TSHRMAPK1 | |
| SCHEMBL9814281 | 0.81 | CYP3A4 (0.65) | KDM1AHPGDCYP2C9CYP2C19DHFR | |
| SCHEMBL28393840 | 0.81 | IFNAR1 (0.44) | KDM1AHPGDTSHRMAPK1SIRT2 | |
| SCHEMBL7201257 | 0.81 | NR1H2 (0.48) | CYP2C9CYP2C19DHFRMAPK1SIRT2 | |
| SCHEMBL13730600 | 0.81 | SMN1; SMN2 (0.47) | CYP2C9CYP2C19DHFRCYP3A4MAPK1 | |
| SCHEMBL9923541 | 0.81 | IFNAR1 (0.47) | CYP2C9DHFRCYP3A4MAPK1SIRT2 | |
| SCHEMBL28850516 | 0.81 | DHFR (0.46) | HPGDDHFRCYP3A4TSHRMAPK1 | |
| SCHEMBL9814267 | 0.79 | CYP3A4 (0.70) | KDM1AHPGDCYP2C9CYP2C19DHFR | |
| SCHEMBL31167972 | 0.79 | IFNAR1 (0.60) | HPGDCYP2C9CYP2C19CYP3A4TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5814646-A | TREATING THE PROGRESSION OF ALZHEIMER'S DISEASE, BRAIN DISORDERS | ELI LILLY AND COMPANY (US) | 1998-09-29 | — | — | US | disclosed |
| US-5624937-A | TREATMENT OF ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1997-04-29 | — | — | US | disclosed |
| EP-0013414-B1 | UREA DERIVATIVES, PROCESS FOR THEIR PREPARATION AND THEIR USE AS INSECTICIDES | CELAMERCK GmbH & Co. KG (DE) | 1982-06-23 | — | — | EP | disclosed |
| US-4275077-A | Insecticidal acyl urea derivatives | CELAMERCK GMBH & CO. KG (DE) | 1981-06-23 | — | — | US | disclosed |
| EP-0013414-A2 | Urea derivatives, process for their preparation and their use as insecticides | CELAMERCK GmbH & Co. KG (DE) | 1980-07-23 | — | — | EP | disclosed |