Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM2 | Q14416 | 2/20 | 0.49 |
| ▸ | GRM3 | Q14832 | 2/20 | 0.49 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.49 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.49 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.49 |
| ▸ | ALPI | P09923 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | XIAP | P98170 | 1/20 | 0.47 |
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.47 |
| ▸ | GRIK1 | P39086 | 4/20 | 0.44 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.43 |
| ▸ | KIF11 | P52732 | 4/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557443 | 0.84 | SIRT5 (0.51) | GRM2GRM3SLC1A1SLC1A3SLC1A2 | |
| SCHEMBL8557449 | 0.84 | SIRT5 (0.51) | GRM2GRM3SLC1A1SLC1A3SLC1A2 | |
| SCHEMBL27889659 | 0.79 | HTT (0.47) | ALPIPKMPTGS1XIAPSLC7A5 | |
| SCHEMBL8564937 | 0.76 | GRM2 (0.39) | GRM2GRM3SLC1A1SLC1A3SLC1A2 | |
| SCHEMBL22338605 | 0.76 | CPA1 (0.42) | PKMHTT | |
| SCHEMBL8564931 | 0.76 | GRM2 (0.39) | GRM2GRM3SLC1A1SLC1A3SLC1A2 | |
| SCHEMBL1931269 | 0.76 | HTT (0.71) | PKMHTT | |
| SCHEMBL10824817 | 0.76 | ALDH1A1 (0.51) | HTT | |
| SCHEMBL9099120 | 0.76 | HTT (0.71) | PKMHTT | |
| SCHEMBL9666324 | 0.73 | ALDH1A1 (0.49) | PKMHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5843997-A | Excitatory amino acid receptor antagonists | ELI LILLY AND COMPANY (US) | 1998-12-01 | — | — | US | disclosed |
| US-5576323-A | CENTRAL NERVOUS SYSTEM DISORDERS | ELI LILLY AND COMPANY (US) | 1996-11-19 | — | — | US | disclosed |