Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 2/20 | 0.50 |
| ▸ | AVPR1A | P37288 | 5/20 | 0.46 |
| ▸ | AVPR2 | P30518 | 3/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.43 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.43 |
| ▸ | RELA | Q04206 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
| ▸ | AVPR1B | P47901 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557088 | 0.86 | AVPR1A (0.48) | AVPR1AAVPR2NAMPTGRM1AVPR1B | |
| SCHEMBL8563655 | 0.84 | AVPR1A (0.40) | AVPR1AAVPR2NPC1RAB9AMEN1 | |
| SCHEMBL8559901 | 0.84 | AVPR2 (0.63) | AVPR1AAVPR2 | |
| SCHEMBL8562420 | 0.82 | AVPR2 (0.46) | AVPR1AAVPR2NPC1RAB9AMEN1 | |
| SCHEMBL8558298 | 0.82 | AVPR2 (0.55) | AVPR1AAVPR2 | |
| SCHEMBL8561211 | 0.81 | GRM1 (0.48) | PKMAVPR1AAVPR2NPC1RAB9A | |
| SCHEMBL8560108 | 0.80 | AVPR2 (0.38) | AVPR1AAVPR2NPC1RAB9AMEN1 | |
| SCHEMBL8557927 | 0.80 | AVPR2 (0.51) | AVPR1AAVPR2 | |
| SCHEMBL8561948 | 0.80 | AVPR2 (0.51) | AVPR1AAVPR2 | |
| SCHEMBL8558577 | 0.79 | AVPR2 (0.57) | AVPR1AAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |