Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.39 |
| ▸ | PDE9A | O76083 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.33 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.33 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.33 |
| ▸ | MET | P08581 | 1/20 | 0.33 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.33 |
| ▸ | FLT1 | P17948 | 1/20 | 0.33 |
| ▸ | LTK | P29376 | 1/20 | 0.33 |
| ▸ | GRK5 | P34947 | 1/20 | 0.33 |
| ▸ | CDK8 | P49336 | 1/20 | 0.33 |
| ▸ | PRKX | P51817 | 1/20 | 0.33 |
| ▸ | NEK2 | P51955 | 1/20 | 0.33 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.33 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.33 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.33 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.33 |
| ▸ | PRKAA1 | Q13131 | 1/20 | 0.33 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.33 |
| ▸ | IKBKE | Q14164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8557418 | 0.82 | PDE5A (0.49) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL8553369 | 0.78 | PDE5A (0.45) | PDE5APDE9ACHEK1DAPK3PRKD3 | |
| SCHEMBL8558977 | 0.73 | PDE5A (0.38) | PDE5APDE9ACHEK1DAPK3PRKD3 | |
| SCHEMBL31328139 | 0.73 | PDE5A (0.52) | PDE5APDE9ACHEK1DAPK3PRKD3 | |
| SCHEMBL7505355 | 0.73 | PDE5A (0.52) | PDE5APDE9ACHEK1DAPK3PRKD3 | |
| SCHEMBL7517883 | 0.72 | PDE5A (0.48) | PDE5APDE9ACHEK1DAPK3PRKD3 | |
| SCHEMBL7503779 | 0.71 | CHEK1 (0.55) | PDE5APDE9ACHEK1DAPK3PRKD3 | |
| SCHEMBL8557784 | 0.71 | PDE5A (0.47) | PDE5APDE9AMEN1KMT2ACYP1A2 | |
| SCHEMBL8554724 | 0.70 | PDE5A (0.48) | PDE5APDE9ACHEK1DAPK3PRKD3 | |
| SCHEMBL8557015 | 0.70 | PDE9A (0.47) | PDE5APDE9AMEN1KMT2ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0691970-B1 | IMIDAZOLOQUINOXALINONE DERIVATIVES AS EAA ANTAGONISTS | BASF AG (DE) | 1998-11-11 | — | — | EP | disclosed |