Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 2/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | CTSD | P07339 | 1/20 | 0.37 |
| ▸ | CES2 | O00748 | 2/20 | 0.36 |
| ▸ | CES1 | P23141 | 2/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GABBR2 | O75899 | 1/20 | 0.35 |
| ▸ | GABBR1 | Q9UBS5 | 1/20 | 0.35 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.34 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.34 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.34 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1375360 | 0.81 | SRC (0.64) | SRCCYP2D6LMNAMAPK1CTSD | |
| SCHEMBL11680362 | 0.79 | SRC (0.56) | SRCCYP2D6LMNAMAPK1CTSD | |
| SCHEMBL10677605 | 0.77 | SRC (0.73) | SRCCYP2D6LMNAMAPK1CTSD | |
| SCHEMBL28033698 | 0.74 | SRC (0.54) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL170040 | 0.69 | SRC (0.67) | SRCCYP2D6LMNAMAPK1CTSD | |
| SCHEMBL11679477 | 0.69 | KMT2A (0.60) | SRCLMNA | |
| SCHEMBL271454 | 0.69 | SRC (0.43) | SRCCYP2D6LMNAMAPK1CES2 | |
| SCHEMBL15151130 | 0.69 | CYP2D6 (0.46) | SRCCYP2D6LMNAMAPK1CTSD | |
| SCHEMBL10932246 | 0.69 | CYP2D6 (0.46) | SRCCYP2D6LMNAMAPK1CTSD | |
| SCHEMBL2594496 | 0.69 | CYP2D6 (0.46) | SRCCYP2D6LMNAMAPK1CTSD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0710230-B1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO WELLCOME SPA (IT) | 1998-09-16 | — | — | EP | disclosed |
| US-5716953-A | MODIFIERS OF GASTRIN AND CHOLECYSTOKININS | GLAXO WELLCOME S.P.A. (IT) | 1998-02-10 | — | — | US | disclosed |
| US-5686449-A | 1,5-benzodiazepines useful as gastrinor CCK-antagonists | GLAXO WELLCOME S.P.A. (IT) | 1997-11-11 | — | — | US | disclosed |
| EP-0710230-A1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO S.p.A. (IT) | 1996-05-08 | — | — | EP | disclosed |
| EP-0695297-A1 | 1,5-BENZODIAZEPINES USEFUL AS GASTRIN OR CCK-ANTAGONISTS | GLAXO S.p.A. (IT) | 1996-02-07 | — | — | EP | disclosed |
| WO-1995003285-A1 | 1,5-BENZODIAZEPINE DERIVATIVES USEFUL AS CCK OR GASTRIN ANTAGONISTS | GLAXO SPA (IT) | 1995-02-02 | — | — | WO | disclosed |
| WO-1994025445-A1 | 1,5-BENZODIAZEPINES USEFUL AS GASTRIN OR CCK-ANTAGONISTS | GLAXO S.P.A. (IT) | 1994-11-10 | — | — | WO | disclosed |