Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.73 |
| ▸ | NPC1 | O15118 | 3/20 | 0.73 |
| ▸ | RAB9A | P51151 | 3/20 | 0.73 |
| ▸ | LMNA | P02545 | 3/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 2/20 | 0.72 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.71 |
| ▸ | HPGD | P15428 | 4/20 | 0.71 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.71 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.71 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.71 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.71 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.71 |
| ▸ | MEN1 | O00255 | 3/20 | 0.66 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.66 |
| ▸ | PLA2G1B | P04054 | 1/20 | 0.65 |
| ▸ | ATG4B | Q9Y4P1 | 1/20 | 0.65 |
| ▸ | RIPK1 | Q13546 | 1/20 | 0.64 |
| ▸ | GRIN2B | Q13224 | 2/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5504989 | 0.90 | MAPT (0.73) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL18757895 | 0.80 | TXN (0.70) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL15693643 | 0.79 | MAPT (0.67) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL6210308 | 0.78 | KCNH2 (0.84) | MAPTLMNAHTTALDH1A1NPSR1 | |
| SCHEMBL15693641 | 0.78 | MAPT (0.75) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL6773598 | 0.78 | RIPK1 (1.00) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL28720173 | 0.78 | HTT (0.76) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL15693637 | 0.78 | HTT (0.69) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL15693638 | 0.78 | HTT (0.69) | MAPTSMN1; SMN2NPC1RAB9ALMNA | |
| SCHEMBL28721480 | 0.77 | SMN1; SMN2 (0.72) | MAPTSMN1; SMN2NPC1RAB9ALMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0843671-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1998-05-27 | — | — | EP | disclosed |
| WO-1997003069-A1 | HETEROCYCLIC COMPOUNDS AND PHARMACEUTICAL COMPOSITIONS CONTAINING THEM | GLAXO GROUP LIMITED (GB) | 1997-01-30 | — | — | WO | disclosed |