SCHEMBL8559348

SCHEMBL8559348

Cc1ccc(C2C(=O)NC3(CCCCC3)C2=O)c(Cl)c1

nearest known ligand 0.45

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PDE7A Q13946 13/20 0.45
PDE7B Q9NP56 1/20 0.38
KMT2A Q03164 2/20 0.38
POLB P06746 1/20 0.38
NPC1 O15118 2/20 0.35
RAB9A P51151 2/20 0.35
L3MBTL1 Q9Y468 1/20 0.35
THRB P10828 1/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL12496757 0.88 PDE7A (0.45) PDE7APDE7B
SCHEMBL7769002 0.86 KMT2A (0.42) PDE7AKMT2APOLBNPC1RAB9A
SCHEMBL8863053 0.86 KMT2A (0.42) PDE7AKMT2APOLBNPC1RAB9A
SCHEMBL4428399 0.85 PDE7A (0.47) PDE7APDE7BKMT2A
SCHEMBL8559775 0.85 TSHR (0.38) PDE7APDE7BNPC1RAB9A
SCHEMBL6294797 0.84 ACACB (0.42) PDE7AKMT2A
SCHEMBL4434523 0.82 PDE7A (0.39) PDE7APDE7B
SCHEMBL3893209 0.79 CA1 (0.33)
SCHEMBL8905942 0.76 GAA (0.42) PDE7AKMT2ATHRB
SCHEMBL1812688 0.76 PDE7A (0.44) PDE7AKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-5959055-A Ethylene/polyalkyleneglycol (ether) (meth)acrylic ester copolymer and nonporous breathable film obtained therefrom ELF ATOCHEM S.A. (FR) 1999-09-28 US disclosed
US-5959055-A Ethylene/polyalkyleneglycol (ether) (meth)acrylic ester copolymer and nonporous breathable film obtained therefrom ELF ATOCHEM S.A. (FR) 1999-09-28 US disclosed
US-5847211-A Substituted 1H-3-Aryl-pyrrolidine-2,4-dione derivatives BAYER AKTIENGESELLSCHAFT (DE) 1998-12-08 US disclosed
EP-0848019-A1 Ethylene/polyalkyleneglycol (meth)acrylate copolymer and respiration active waterproof film obtained therefrom ELF ATOCHEM S.A. (FR) 1998-06-17 EP disclosed
EP-0848019-A1 Ethylene/polyalkyleneglycol (meth)acrylate copolymer and respiration active waterproof film obtained therefrom ELF ATOCHEM S.A. (FR) 1998-06-17 EP disclosed
EP-0848019-A1 Ethylene/polyalkyleneglycol (meth)acrylate copolymer and respiration active waterproof film obtained therefrom ELF ATOCHEM S.A. (FR) 1998-06-17 EP disclosed
EP-0668267-B1 Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives BAYER AG (DE) 1998-04-08 EP disclosed
US-5622917-A PESTICIDES BAYER AKTIENGESELLSCHAFT (DE) 1997-04-22 US disclosed
EP-0668267-A1 Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives BAYER AG (DE) 1995-08-23 EP disclosed