Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 2/20 | 0.38 |
| ▸ | PDE7A | Q13946 | 7/20 | 0.37 |
| ▸ | PDE7B | Q9NP56 | 3/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | NPC1 | O15118 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.35 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.35 |
| ▸ | GHSR | Q92847 | 4/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8559348 | 0.85 | PDE7A (0.45) | RAB9APDE7APDE7BNPC1 | |
| SCHEMBL12496757 | 0.83 | PDE7A (0.45) | PDE7APDE7BALDH1A1HTT | |
| SCHEMBL4434523 | 0.82 | PDE7A (0.39) | TSHRPDE7APDE7BALDH1A1 | |
| SCHEMBL4428399 | 0.81 | PDE7A (0.47) | PDE7APDE7B | |
| SCHEMBL1475886 | 0.74 | KMT2A (0.37) | TSHRRAB9APDE7ASMN1; SMN2NPC1 | |
| SCHEMBL5929431 | 0.74 | PDE7A (0.41) | PDE7APDE7BGHSR | |
| SCHEMBL8863053 | 0.74 | KMT2A (0.42) | RAB9APDE7AALDH1A1LMNANPC1 | |
| SCHEMBL7769002 | 0.74 | KMT2A (0.42) | RAB9APDE7AALDH1A1LMNANPC1 | |
| SCHEMBL8905942 | 0.72 | GAA (0.42) | TSHRPDE7AALDH1A1LMNAMAPK1 | |
| SCHEMBL6992901 | 0.71 | ALDH1A1 (0.37) | TSHRRAB9APDE7AALDH1A1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5847211-A | Substituted 1H-3-Aryl-pyrrolidine-2,4-dione derivatives | BAYER AKTIENGESELLSCHAFT (DE) | 1998-12-08 | — | — | US | disclosed |
| EP-0668267-B1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1998-04-08 | — | — | EP | disclosed |
| US-5622917-A | PESTICIDES | BAYER AKTIENGESELLSCHAFT (DE) | 1997-04-22 | — | — | US | disclosed |
| EP-0668267-A1 | Substituted 1H-3-aryl-pyrrolidine-2,4-dione derivatives | BAYER AG (DE) | 1995-08-23 | — | — | EP | disclosed |