Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TRPA1 | O75762 | 4/20 | 0.36 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.34 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 2/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.32 |
| ▸ | RAB9A | P51151 | 1/20 | 0.32 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.32 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.32 |
| ▸ | SNCA | P37840 | 1/20 | 0.32 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL679805 | 0.82 | HIF1A (0.43) | HIF1ALMNATRPA1TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL5180858 | 0.78 | HIF1A (0.42) | HIF1ALMNATRPA1TSHRALDH1A1 | |
| Hydrochloric Acid SCHEMBL2965186 | 0.77 | HIF1A (0.43) | HIF1ALMNATRPA1TSHRALDH1A1 | |
| Water SCHEMBL2822588 | 0.77 | HIF1A (0.43) | HIF1ALMNATRPA1TSHRALDH1A1 | |
| SCHEMBL9752172 | 0.77 | HIF1A (0.43) | HIF1ALMNATRPA1TSHRALDH1A1 | |
| Iodide SCHEMBL5085335 | 0.77 | HIF1A (0.43) | HIF1ALMNATRPA1TSHRALDH1A1 | |
| Fluoride Ion SCHEMBL4618615 | 0.77 | HIF1A (0.43) | HIF1ALMNATRPA1TSHRALDH1A1 | |
| Bromide SCHEMBL11791857 | 0.73 | TP53 (0.39) | HIF1AALDH1A1TDP1SMN1; SMN2TP53 | |
| Bromide SCHEMBL774204 | 0.73 | HIF1A (0.67) | HIF1ATRPA1TSHRALDH1A1CYP1A2 | |
| Bromide SCHEMBL5092433 | 0.73 | HIF1A (0.46) | HIF1ALMNATSHRALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5958906-A | Phospholipid derivatives containing higher elements of the fifth main group | ASTA-MEDICA AKTIENGESELLSCHAFT (DE) | 1999-09-28 | — | — | US | disclosed |
| EP-0594999-B1 | Phospholipid derivatives containing higher elements of the fifth main group | ASTA MEDICA AG (DE) | 1998-12-02 | — | — | EP | disclosed |
| US-5637577-A | TREATMENT OF POTOZOAL DISEASES | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1997-06-10 | — | — | US | disclosed |
| US-5449798-A | Phospholipid derivatives containing higher elements of the fifth group | ASTA MEDICA AKTIENGESELLSCHAFT (DE) | 1995-09-12 | — | — | US | disclosed |
| EP-0594999-A1 | Phospholipid derivatives containing higher elements of the fifth main group | ASTA Medica Aktiengesellschaft (DE) | 1994-05-04 | — | — | EP | disclosed |