Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAOB | P27338 | 4/20 | 0.62 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.59 |
| ▸ | MRGPRX4 | Q96LA9 | 3/20 | 0.55 |
| ▸ | MAPT | P10636 | 3/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.54 |
| ▸ | RXRA | P19793 | 2/20 | 0.54 |
| ▸ | RXRB | P28702 | 1/20 | 0.54 |
| ▸ | RXRG | P48443 | 1/20 | 0.54 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.53 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.53 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.52 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | RAB9A | P51151 | 1/20 | 0.52 |
| ▸ | SMPD1 | P17405 | 1/20 | 0.50 |
| ▸ | ATM | Q13315 | 1/20 | 0.50 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20463436 | 0.89 | MAOB (0.64) | MAOBMRGPRX4MAPTKDM4EALDH1A1 | |
| SCHEMBL20456188 | 0.89 | MRGPRX4 (0.70) | MAOBMRGPRX4MAPTRXRARXRB | |
| SCHEMBL22386763 | 0.88 | MRGPRX4 (0.58) | MAOBMRGPRX4MAPTKDM4EALDH1A1 | |
| SCHEMBL20463488 | 0.88 | MRGPRX4 (0.58) | MAOBMRGPRX4MAPTKDM4EALDH1A1 | |
| SCHEMBL22386778 | 0.86 | MRGPRX4 (0.54) | MAOBMRGPRX4MAPTKDM4EALDH1A1 | |
| SCHEMBL22386726 | 0.85 | MRGPRX4 (0.53) | MAOBMRGPRX4MAPTKDM4EALDH1A1 | |
| SCHEMBL12112529 | 0.85 | SMN1; SMN2 (0.57) | MAOBMRGPRX4MAPTKDM4EALDH1A1 | |
| SCHEMBL856030 | 0.85 | RXRA (0.70) | MAOBMRGPRX4RXRARXRBRXRG | |
| SCHEMBL20456200 | 0.84 | SMN1; SMN2 (0.56) | MAOBMRGPRX4MAPTRXRARXRB | |
| SCHEMBL7368681 | 0.83 | NPC1 (0.62) | MRGPRX4KDM4ERXRARXRBRXRG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |