Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RXRA | P19793 | 2/20 | 0.70 |
| ▸ | RXRB | P28702 | 2/20 | 0.70 |
| ▸ | RXRG | P48443 | 2/20 | 0.70 |
| ▸ | MAOB | P27338 | 5/20 | 0.65 |
| ▸ | MRGPRX4 | Q96LA9 | 7/20 | 0.57 |
| ▸ | PARP1 | P09874 | 1/20 | 0.47 |
| ▸ | PARP10 | Q53GL7 | 2/20 | 0.47 |
| ▸ | PTPN1 | P18031 | 2/20 | 0.45 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.45 |
| ▸ | PTPN6 | P29350 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL855955 | 0.85 | MAOB (0.62) | RXRARXRBRXRGMAOBMRGPRX4 | |
| SCHEMBL3176541 | 0.80 | S1PR1 (0.48) | RXRARXRBRXRGMAOBMRGPRX4 | |
| SCHEMBL30576796 | 0.79 | MAOB (1.00) | MAOBMRGPRX4PARP10 | |
| SCHEMBL30354958 | 0.79 | MAOB (0.60) | RXRARXRBRXRGMAOBMRGPRX4 | |
| SCHEMBL30417785 | 0.77 | MAOB (0.76) | MAOBMRGPRX4PTPN1PTPN2PTPN6 | |
| SCHEMBL7442111 | 0.77 | MAOB (0.76) | MAOBMRGPRX4PTPN1PTPN2PTPN6 | |
| SCHEMBL79709 | 0.77 | RXRA (0.72) | RXRARXRBRXRGMRGPRX4 | |
| SCHEMBL3427596 | 0.77 | S1PR1 (0.46) | RXRARXRBRXRGMAOBMRGPRX4 | |
| SCHEMBL856364 | 0.76 | RXRA (0.59) | RXRARXRBRXRGMAOBPTPN1 | |
| SCHEMBL8337229 | 0.75 | MAOB (0.53) | RXRARXRBRXRGMAOBMRGPRX4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143271-B2 | Compounds and methods for kinase modulation, and indications therefor | PLEXXIKON INC. (US) | 2012-03-27 | — | — | US | disclosed |