Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AGTR1 | P30556 | 3/20 | 0.41 |
| ▸ | AGTR2 | P50052 | 3/20 | 0.41 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.39 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.39 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.39 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.39 |
| ▸ | SLCO1B3 | Q9NPD5 | 1/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560871 | 0.94 | AGTR1 (0.41) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL8558488 | 0.87 | AGTR1 (0.49) | AGTR1AGTR2 | |
| SCHEMBL7886496 | 0.81 | AGTR1 (0.44) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL8562435 | 0.80 | AGTR1 (0.55) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL8561080 | 0.80 | AGTR1 (0.48) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL7313176 | 0.79 | — | — | |
| SCHEMBL8563803 | 0.78 | AGTR1 (0.54) | AGTR1AGTR2 | |
| SCHEMBL8560944 | 0.77 | AGTR1 (0.55) | AGTR1AGTR2ABCC3ABCC4ABCB11 | |
| SCHEMBL7883494 | 0.77 | — | — | |
| Hydrochloric Acid SCHEMBL7878363 | 0.76 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0603001-B1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO CO (JP) | 1998-08-26 | — | — | EP | disclosed |
| US-5459148-A | Cardiovascular disorders | SANKYO COMPANY, LIMITED (JP) | 1995-10-17 | — | — | US | disclosed |
| EP-0603001-A1 | Biphenyl derivatives, their preparation and their use for the treatment of hypertension and cardiac disease | SANKYO COMPANY LIMITED (JP) | 1994-06-22 | — | — | EP | disclosed |