Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BCHE | P06276 | 3/20 | 0.67 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.47 |
| ▸ | SNCA | P37840 | 1/20 | 0.47 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | USP2 | O75604 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | AVPR2 | P30518 | 1/20 | 0.43 |
| ▸ | AVPR1A | P37288 | 1/20 | 0.43 |
| ▸ | ACHE | P22303 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8556386 | 0.86 | BCHE (0.52) | BCHEHPGDMAPTSMN1; SMN2LMNA | |
| SCHEMBL8557987 | 0.82 | AVPR2 (0.53) | BCHEHPGDSMN1; SMN2P2RX4ALDH1A1 | |
| SCHEMBL7330482 | 0.81 | HPGD (0.54) | BCHEHPGDMAPTSMN1; SMN2LMNA | |
| SCHEMBL10490281 | 0.80 | BCHE (1.00) | BCHEMAPTSMN1; SMN2LMNAGAA | |
| SCHEMBL7347407 | 0.78 | BCHE (0.59) | BCHEHPGDMAPTSMN1; SMN2LMNA | |
| SCHEMBL8557423 | 0.76 | ACHE (0.51) | AVPR2AVPR1AACHE | |
| SCHEMBL7348893 | 0.76 | BCHE (0.56) | BCHEHPGDMAPTSMN1; SMN2LMNA | |
| SCHEMBL14509685 | 0.74 | HPGD (0.47) | BCHEHPGDMAPTLMNAGAA | |
| SCHEMBL31332440 | 0.74 | HSD17B3 (0.68) | BCHE | |
| SCHEMBL7340479 | 0.74 | AVPR1A (0.74) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |