SCHEMBL8560077

SCHEMBL8560077

COCC(=O)Nc1ccc(/C=C/C(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Cl)c(C)nc34)c2Cl)cc1

nearest known ligand 0.75

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.75

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8560079 1.00 BDKRB2 (0.75) BDKRB2
Hydrochloric Acid SCHEMBL8567348 0.99 BDKRB2 (0.75) BDKRB2
Hydrochloric Acid SCHEMBL8567349 0.99 BDKRB2 (0.75) BDKRB2
SCHEMBL8561728 0.94 BDKRB2 (0.73) BDKRB2
SCHEMBL8565797 0.94 BDKRB2 (0.86) BDKRB2
SCHEMBL8565795 0.94 BDKRB2 (0.86) BDKRB2
SCHEMBL8562978 0.94 BDKRB2 (0.77) BDKRB2
Hydrochloric Acid SCHEMBL8560180 0.93 BDKRB2 (0.86) BDKRB2
Hydrochloric Acid SCHEMBL8567174 0.93 BDKRB2 (0.74) BDKRB2
Hydrochloric Acid SCHEMBL8560177 0.93 BDKRB2 (0.86) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
US-5574042-A ANTAGONIST FOR BRADYKININS AS ANTIALLERGENS, AUTOIMMUNE DISEASES, ANTIINFLAMMATORY AGENTS, SHOCK OR PAIN FUJISAWA PHARMACEUTICAL CO., LTD (JP) 1996-11-12 US disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed