SCHEMBL8561728

SCHEMBL8561728

COCCC(=O)Nc1ccc(C=CC(=O)NCC(=O)N(C)c2ccc(Cl)c(COc3cccn4c(Cl)c(C)nc34)c2Cl)cc1

nearest known ligand 0.73

Predicted protein targets (top 1)

geneUniProtsupporting neighboursconfidence
BDKRB2 P30411 20/20 0.73

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Hydrochloric Acid SCHEMBL8567174 0.99 BDKRB2 (0.74) BDKRB2
SCHEMBL8567966 0.94 BDKRB2 (0.84) BDKRB2
SCHEMBL8560077 0.94 BDKRB2 (0.75) BDKRB2
SCHEMBL8560079 0.94 BDKRB2 (0.75) BDKRB2
Hydrochloric Acid SCHEMBL8566627 0.93 BDKRB2 (0.84) BDKRB2
Hydrochloric Acid SCHEMBL8567348 0.93 BDKRB2 (0.75) BDKRB2
Hydrochloric Acid SCHEMBL8567349 0.93 BDKRB2 (0.75) BDKRB2
SCHEMBL8562978 0.92 BDKRB2 (0.77) BDKRB2
Hydrochloric Acid SCHEMBL8565870 0.92 BDKRB2 (0.77) BDKRB2
SCHEMBL8559941 0.92 BDKRB2 (0.80) BDKRB2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0596406-B1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO (JP) 1998-12-16 EP disclosed
EP-0596406-A1 Imidazo (1,2-a) Pyridines as bradykinin antagonists FUJISAWA PHARMACEUTICAL CO., LTD. (JP) 1994-05-11 EP disclosed