Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KEAP1 | Q14145 | 1/20 | 0.83 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.83 |
| ▸ | HPGD | P15428 | 1/20 | 0.46 |
| ▸ | DUSP3 | P51452 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | GAA | P10253 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | KDM1A | O60341 | 1/20 | 0.44 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703703 | 1.00 | KEAP1 (0.83) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL5988693 | 1.00 | KEAP1 (0.83) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL3200530 | 1.00 | KEAP1 (0.83) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL5903339 | 1.00 | KEAP1 (0.83) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL179978 | 0.98 | KEAP1 (0.86) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL19922 | 0.91 | KEAP1 (1.00) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| SCHEMBL13878256 | 0.90 | KEAP1 (0.73) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| Hydrochloric Acid SCHEMBL11880824 | 0.88 | KEAP1 (0.95) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| Hydrochloric Acid SCHEMBL8934456 | 0.88 | KEAP1 (0.95) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E | |
| Ammonia Solution, Strong SCHEMBL1579906 | 0.88 | KEAP1 (0.95) | KEAP1SMN1; SMN2HPGDDUSP3KDM4E |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575954-B1 | Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase acitivity inhibitors and relative preparation process | MEDIOLANUM FARMACEUTICI SRL (IT) | 1998-09-02 | — | — | EP | disclosed |
| US-5424451-A | Used as cholinesterase activity inhibitors | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1995-06-13 | — | — | US | disclosed |
| US-5302593-A | Aminoalkylcarbamic esters of eseroline suitable for use as chlorinesterase activity inhibitors | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1994-04-12 | — | — | US | disclosed |
| EP-0575954-A1 | Aminoalkylcarbamic esters of eseroline suitable for use as cholinesterase acitivity inhibitors and relative preparation process | MEDIOLANUM FARMACEUTICI S.P.A. (IT) | 1993-12-29 | — | — | EP | disclosed |