Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 8/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.37 |
| ▸ | MAPT | P10636 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | TP53 | P04637 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | THRB | P10828 | 1/20 | 0.36 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.36 |
| ▸ | CDK1 | P06493 | 1/20 | 0.36 |
| ▸ | CCNB1 | P14635 | 1/20 | 0.36 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.36 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560142 | 1.00 | DPP4 (0.42) | DPP4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL8322260 | 0.81 | DPP4 (0.48) | DPP4MAPTTSHRKDM4ENPC1 | |
| SCHEMBL8565165 | 0.81 | PDE4B (0.52) | ALDH1A1MAPTSMN1; SMN2GAATP53 | |
| SCHEMBL8565169 | 0.81 | PDE4B (0.52) | ALDH1A1MAPTSMN1; SMN2GAATP53 | |
| SCHEMBL8558995 | 0.81 | DPP4 (0.46) | DPP4ALDH1A1MAPTSMN1; SMN2LMNA | |
| Hydrochloric Acid SCHEMBL8327789 | 0.80 | PDE4B (0.51) | ALDH1A1MAPTSMN1; SMN2GAATP53 | |
| SCHEMBL8324234 | 0.74 | DPP4 (0.51) | DPP4MAPTSMN1; SMN2LMNATSHR | |
| SCHEMBL8324245 | 0.73 | TSHR (0.42) | DPP4ALDH1A1MAPTSMN1; SMN2LMNA | |
| SCHEMBL8325264 | 0.72 | PDE4B (0.51) | ALDH1A1MAPTSMN1; SMN2GAATP53 | |
| SCHEMBL8327280 | 0.72 | PDE4B (0.51) | ALDH1A1MAPTSMN1; SMN2GAATP53 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |