SCHEMBL8324245

SCHEMBL8324245

CCOc1cc2c(O)c(C(=O)O)cnc2nc1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
TSHR P16473 3/20 0.42
HSD17B10 Q99714 2/20 0.42
CASP3 P42574 1/20 0.41
CASP7 P55210 1/20 0.41
CASP9 P55211 1/20 0.41
KDM4E B2RXH2 5/20 0.41
SMN1; SMN2 Q16637 4/20 0.41
ALDH1A1 P00352 3/20 0.41
HPGD P15428 3/20 0.41
CYP1A2 P05177 1/20 0.41
TP53 P04637 2/20 0.39
DPP4 P27487 4/20 0.39
CYP3A4 P08684 1/20 0.39
LMNA P02545 3/20 0.38
MAPT P10636 1/20 0.38
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
GABRP O00591 1/20 0.36
GABRD O14764 1/20 0.36
GABRA1 P14867 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27446746 0.90 TP53 (0.41) TSHRHSD17B10CASP3CASP7CASP9
SCHEMBL8328855 0.88 DPP4 (0.40) TSHRDPP4CYP3A4LMNA
SCHEMBL8322260 0.88 DPP4 (0.48) TSHRKDM4EDPP4MAPTNPC1
SCHEMBL8326372 0.87 TSHR (0.40) TSHRHSD17B10KDM4ESMN1; SMN2ALDH1A1
SCHEMBL8562829 0.87 ALDH1A1 (0.38) TSHRHSD17B10ALDH1A1HPGDDPP4
SCHEMBL8565727 0.81 KDM4E (0.33) TSHRHSD17B10KDM4ESMN1; SMN2ALDH1A1
SCHEMBL8324234 0.80 DPP4 (0.51) TSHRHSD17B10KDM4ESMN1; SMN2DPP4
SCHEMBL8558995 0.80 DPP4 (0.46) TSHRCASP3CASP7CASP9KDM4E
SCHEMBL8329028 0.79 THRB (0.38) KDM4ETP53MAPT
SCHEMBL8561182 0.79 HSD17B10 (0.36) TSHRHSD17B10KDM4ESMN1; SMN2ALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0705260-B1 CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY KNOLL AG (DE) 1999-03-03 EP disclosed
EP-0618916-B1 ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES KNOLL AG (DE) 1998-09-23 EP disclosed
US-5780482-A TREATING RHEUMATIC DISEASES KNOLL AKTIENGESELLSCHAFT (DE) 1998-07-14 US disclosed
EP-0705260-A1 CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY KNOLL AKTIENGESELLSCHAFT (DE) 1996-04-10 EP disclosed
US-5464781-A TREATING RHEUMATIC DISEASES THE BOOTS COMPANY PLC (GB) 1995-11-07 US disclosed
WO-1995000511-A1 CONDENSED 4-AMINOPYRIDINES WITH ANTIRHEUMATIC ACTIVITY KNOLL AG (DE) 1995-01-05 WO disclosed
EP-0618916-A1 ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES Knoll AG (DE) 1994-10-12 EP disclosed
WO-1993013097-A1 ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES THE BOOTS COMPANY PLC (GB) 1993-07-08 WO disclosed