Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 4/20 | 0.51 |
| ▸ | MEN1 | O00255 | 3/20 | 0.51 |
| ▸ | MAPT | P10636 | 8/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.44 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | DPP4 | P27487 | 5/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Water SCHEMBL8560641 | 0.85 | MAPT (0.45) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL620724 | 0.82 | MAPT (0.61) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL8327645 | 0.81 | KMT2A (0.51) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL8566663 | 0.78 | KMT2A (0.51) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL8565920 | 0.77 | DPP4 (0.52) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL8322999 | 0.76 | KMT2A (0.58) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL5929779 | 0.76 | KMT2A (0.54) | KMT2AMEN1MAPTALDH1A1HPGD | |
| SCHEMBL9875486 | 0.76 | KMT2A (0.60) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL2022576 | 0.76 | KMT2A (0.60) | KMT2AMEN1MAPTALDH1A1LMNA | |
| SCHEMBL544894 | 0.75 | MAPT (0.62) | KMT2AMEN1MAPTALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0618916-B1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | KNOLL AG (DE) | 1998-09-23 | — | — | EP | disclosed |
| US-5464781-A | TREATING RHEUMATIC DISEASES | THE BOOTS COMPANY PLC (GB) | 1995-11-07 | — | — | US | disclosed |
| WO-1993013097-A1 | ANTI-RHEUMATIC NAPHTHYRIDINE DERIVATIVES | THE BOOTS COMPANY PLC (GB) | 1993-07-08 | — | — | WO | disclosed |