⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9889349 | 0.73 | — | — | |
| SCHEMBL13248108 | 0.72 | — | — | |
| SCHEMBL1710152 | 0.72 | ALDH1A1 (0.31) | — | |
| Bromide SCHEMBL31141387 | 0.71 | — | — | |
| Bromide SCHEMBL31141398 | 0.71 | — | — | |
| Cyclocreatine SCHEMBL450343 | 0.71 | CYP2D6 (0.39) | — | |
| SCHEMBL12647102 | 0.70 | — | — | |
| SCHEMBL14537232 | 0.69 | BDKRB2 (0.33) | — | |
| Cyclocreatine SCHEMBL11796002 | 0.69 | CYP2D6 (0.38) | — | |
| SCHEMBL19719147 | 0.69 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1642588-A2 | Mimetics of interleukin-8 and methods of using them in the prevention, treatment, diagnosis, and ameliorization of symptoms of a disease | Chemokine Therapeutics Corporation (CA) | 2006-04-05 | — | — | EP | claimed |
| US-20240218034-A1 | MACROCYCLIC MODULATORS OF DISEASE ASSOCIATED PROTEIN MISFOLDING AND AGGREGATION | RESQ BIOTECH (GR) | 2024-07-04 | — | — | US | disclosed |
| US-11858974-B2 | Macrocyclic modulators of disease associated protein misfolding and aggregation | RESQ BIOTECH (GR) | 2024-01-02 | — | — | US | disclosed |
| EP-4218784-A2 | MACROCYCLIC MODULATORS OF DISEASE ASSOCIATED PROTEIN MISFOLDING AND AGGREGATION | National Hellenic Research Foundation (GR) | 2023-08-02 | — | — | EP | disclosed |
| US-20200140506-A1 | MACROCYCLIC MODULATORS OF DISEASE ASSOCIATED PROTEIN MISFOLDING AND AGGREGATION | NATIONAL HELLENIC RESEARCH FOUNDATION (GR) | 2020-05-07 | — | — | US | disclosed |
| EP-3630153-A2 | MACROCYCLIC MODULATORS OF DISEASE ASSOCIATED PROTEIN MISFOLDING AND AGGREGATION | National Hellenic Research Foundation (GR) | 2020-04-08 | — | — | EP | disclosed |
| WO-2018215831-A2 | MACROCYCLIC MODULATORS OF DISEASE ASSOCIATED PROTEIN MISFOLDING AND AGGREGATION | NATIONAL HELLENIC RESEARCH FOUNDATION (GR) | 2018-11-29 | — | — | WO | disclosed |
| US-9290751-B2 | LPL variant therapeutics | Hayden, Michael R. (CA) | 2016-03-22 | — | — | US | disclosed |
| US-20150030581-A1 | LPL VARIANT THERAPEUTICS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2015-01-29 | — | — | US | disclosed |
| US-8268778-B2 | Flavivirus NS5A proteins for the treatment of HIV | UNIVERSITY OF IOWA RESEARCH FOUNDATION (US) | 2012-09-18 | — | — | US | disclosed |
| WO-2000052048-A1 | MODULATORS OF BETA-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 2000-09-08 | — | — | WO | disclosed |
| WO-2000009152-A1 | THERAPEUTIC CHEMOKINE RECEPTOR ANTAGONISTS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 2000-02-24 | — | — | WO | disclosed |
| US-5985242-A | PEPTIDE OF 3 TO 5 D-AMINO ACIDS; MAY BE MODIFIED AT AMINO-AND/OR CARBOXY TERMINUS; FOR TREATMENT OF AMYLOIDOSIS, ALZHEIMER'S DISEASE | PRAECIS PHARMACEUTICALS, INC. (US) | 1999-11-16 | — | — | US | disclosed |
| WO-1999047158-A2 | THERAPEUTIC CHEMOKINE RECEPTOR ANTAGONISTS | THE UNIVERSITY OF BRITISH COLUMBIA (CA) | 1999-09-23 | — | — | WO | disclosed |
| EP-0929574-A1 | MODULATORS OF beta-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS | Praecis Pharmaceuticals Incorporated (US) | 1999-07-21 | — | — | EP | disclosed |
| US-5854204-A | Aβ peptides that modulate β-amyloid aggregation | PRAECIS PHARMACEUTICALS, INC. (US) | 1998-12-29 | — | — | US | disclosed |
| WO-1998008868-A9 | MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS | — | 1998-05-28 | — | — | WO | disclosed |
| WO-1998008868-A1 | MODULATORS OF β-AMYLOID PEPTIDE AGGREGATION COMPRISING D-AMINO ACIDS | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 1998-03-05 | — | — | WO | disclosed |
| EP-0815134-A1 | MODULATORS OF AMYLOID AGGREGATION | Praecis Pharmaceuticals Incorporated (US) | 1998-01-07 | — | — | EP | disclosed |
| WO-1996028471-A1 | MODULATORS OF AMYLOID AGGREGATION | PRAECIS PHARMACEUTICALS INCORPORATED (US) | 1996-09-19 | — | — | WO | disclosed |