Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR2 | P30518 | 4/20 | 0.52 |
| ▸ | AVPR1A | P37288 | 4/20 | 0.52 |
| ▸ | OXTR | P30559 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.46 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.46 |
| ▸ | RELA | Q04206 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8565429 | 0.87 | GRM1 (0.51) | AVPR2AVPR1A | |
| SCHEMBL8559251 | 0.87 | AVPR2 (0.68) | AVPR2AVPR1AOXTR | |
| SCHEMBL7338784 | 0.85 | AVPR2 (0.52) | AVPR2AVPR1AOXTR | |
| SCHEMBL8564021 | 0.85 | AVPR2 (0.61) | AVPR2AVPR1AOXTR | |
| SCHEMBL8558605 | 0.84 | AVPR2 (0.57) | AVPR2AVPR1AOXTR | |
| SCHEMBL8563255 | 0.84 | AVPR2 (0.59) | AVPR2AVPR1AOXTR | |
| SCHEMBL8563237 | 0.84 | AVPR1A (0.59) | AVPR2AVPR1AOXTR | |
| SCHEMBL8557423 | 0.83 | ACHE (0.51) | AVPR2AVPR1ARAB9A | |
| SCHEMBL8556946 | 0.83 | AVPR2 (0.55) | AVPR2AVPR1AOXTR | |
| SCHEMBL8559312 | 0.83 | AVPR1A (0.55) | AVPR2AVPR1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0640592-B1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID CO (US) | 1998-12-30 | — | — | EP | disclosed |
| EP-0640592-A1 | N-acylated tricyclic azaheterorings useful as vasopressin antagonists | AMERICAN CYANAMID COMPANY (US) | 1995-03-01 | — | — | EP | disclosed |