Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.53 |
| ▸ | MEN1 | O00255 | 2/20 | 0.53 |
| ▸ | FPR2 | P25090 | 1/20 | 0.44 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.41 |
| ▸ | MGLL | Q99685 | 1/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.37 |
| ▸ | TSHR | P16473 | 2/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.36 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.36 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.36 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8560584 | 1.00 | KMT2A (0.53) | KMT2AMEN1FPR2NOTUMMGLL | |
| SCHEMBL28437828 | 0.80 | HDAC1 (0.48) | NOTUMMGLLALDH1A1KDM4EHSD11B1 | |
| SCHEMBL6860135 | 0.80 | CCR1 (0.39) | LMNAALDH1A1SMN1; SMN2TSHROPRM1 | |
| SCHEMBL8567665 | 0.78 | ATM (0.58) | KMT2AMEN1MGLLLMNAALDH1A1 | |
| SCHEMBL8564613 | 0.78 | ALDH1A1 (0.46) | KMT2AMEN1LMNAALDH1A1TSHR | |
| SCHEMBL8567660 | 0.78 | ATM (0.58) | KMT2AMEN1MGLLLMNAALDH1A1 | |
| SCHEMBL8564617 | 0.78 | ALDH1A1 (0.46) | KMT2AMEN1LMNAALDH1A1TSHR | |
| SCHEMBL892631 | 0.76 | NOTUM (0.51) | KMT2AMEN1FPR2NOTUMLMNA | |
| SCHEMBL1514921 | 0.75 | MEN1 (0.50) | KMT2AMEN1FPR2MGLLALDH1A1 | |
| SCHEMBL12285262 | 0.75 | KMT2A (0.47) | KMT2AMEN1FPR2NOTUMMGLL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-1060778-C | Cephalosporin derivatives | HOFFMANN LA ROCHE (CH) | 2001-01-17 | — | — | CN | disclosed |
| US-5804577-A | ANTIBIOTICS | HOFFMANN-LA ROCHE INC. (US) | 1998-09-08 | — | — | US | disclosed |
| CN-1150950-A | Cephalosporin derivatives | HOFFMANN LA ROCHE (CH) | 1997-06-04 | — | — | CN | disclosed |
| EP-0761673-A1 | Cephalosporin derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-12 | — | — | EP | disclosed |