Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.59 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.59 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.59 |
| ▸ | HSD17B10 | Q99714 | 3/20 | 0.59 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.59 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.59 |
| ▸ | LMNA | P02545 | 2/20 | 0.59 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.59 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.59 |
| ▸ | HPGD | P15428 | 1/20 | 0.59 |
| ▸ | RECQL | P46063 | 1/20 | 0.59 |
| ▸ | CA12 | O43570 | 2/20 | 0.48 |
| ▸ | CA1 | P00915 | 2/20 | 0.48 |
| ▸ | CA2 | P00918 | 2/20 | 0.48 |
| ▸ | CA7 | P43166 | 2/20 | 0.48 |
| ▸ | CA9 | Q16790 | 2/20 | 0.48 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.48 |
| ▸ | PDK2 | Q15119 | 1/20 | 0.48 |
| ▸ | PDK4 | Q16654 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 2/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3173889 | 0.87 | CA12 (0.59) | MAPTKDM4EHSD17B10TDP1LMNA | |
| SCHEMBL19615906 | 0.85 | MAPT (0.47) | MAPTKDM4EMAPK1HSD17B10TDP1 | |
| SCHEMBL1434290 | 0.85 | MAPT (0.71) | MAPTKDM4EMAPK1HSD17B10TDP1 | |
| SCHEMBL10542808 | 0.83 | MAPT (0.46) | MAPTKDM4EMAPK1HSD17B10TDP1 | |
| SCHEMBL21828895 | 0.83 | MAPT (0.50) | MAPTKDM4EMAPK1HSD17B10TDP1 | |
| SCHEMBL1553565 | 0.83 | KDM4E (0.51) | MAPTKDM4EMAPK1HSD17B10TDP1 | |
| SCHEMBL13959837 | 0.83 | GAA (0.46) | MAPTKDM4EMAPK1HSD17B10TDP1 | |
| SCHEMBL1560968 | 0.83 | KDM4E (0.47) | MAPTKDM4EMAPK1HSD17B10TDP1 | |
| Methyl 2-Hydroxy-3-Methoxybenzoate SCHEMBL1339162 | 0.82 | TAS1R3 (0.56) | MAPTKDM4EMAPK1HSD17B10ALOX15 | |
| SCHEMBL3189109 | 0.82 | MAPT (0.72) | MAPTKDM4EMAPK1HSD17B10TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 43 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109776551-B | Process for preparing dioxanoquinazoline derivatives | 北京工业大学 | 2020-11-03 | — | — | CN | claimed |
| CN-109776551-A | Dioxanes and quinazoline derivant preparation method | 北京工业大学 | 2019-05-21 | — | — | CN | claimed |
| CN-109776551-B | Process for preparing dioxanoquinazoline derivatives | 北京工业大学 | 2020-11-03 | — | — | CN | disclosed |
| CN-109776551-A | Dioxanes and quinazoline derivant preparation method | 北京工业大学 | 2019-05-21 | — | — | CN | disclosed |
| EP-2114951-B9 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2015-09-02 | — | — | EP | disclosed |
| EP-2114951-B9 | NOVEL PHOSPHODIESTERASE INHIBITORS | LEO PHARMA AS (DK) | 2015-09-02 | — | — | EP | disclosed |
| CN-101631792-B | Novel phosphodiesterase inhibitors | LEO PHARMA AS DK | 2013-05-01 | — | — | CN | disclosed |
| US-8338431-B2 | Phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2012-12-25 | — | — | US | disclosed |
| US-8338431-B2 | Phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2012-12-25 | — | — | US | disclosed |
| US-8338431-B2 | Phosphodiesterase inhibitors | LEO PHARMA A/S (DK) | 2012-12-25 | — | — | US | disclosed |
| US-8334304-B2 | Aminosulfonyl substituted 4-(aminomethyl)-piperidine benzamides as 5HT4-antagonists | JANSSEN PHARMACEUTICA N.V. (BE) | 2012-12-18 | — | — | US | disclosed |
| EP-0837677-B1 | BROMINATED HEXAHYDROXYBIPHENYL DERIVATIVES | UNIV NORTH CAROLINA (US) | 2006-03-29 | — | — | EP | disclosed |
| EP-1638959-A1 | 5HT -4 -ANTAGONISTIC 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2006-03-29 | — | — | EP | disclosed |
| WO-2005003122-A1 | 5HT4-ANTAGONISTIC 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005003121-A1 | HYDROXYCARBONYLPHENYL SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-13 | — | — | WO | disclosed |
| WO-2005000837-A1 | AMINOSULFONYL SUBSTITUTED 4-(AMINOMETHYL)-PIPERIDINE BENZAMIDES AS 5HT4-ANTAGONISTS | JANSSEN PHARMACEUTICA N.V. (BE) | 2005-01-06 | — | — | WO | disclosed |
| EP-0837677-A4 | BROMINATED HEXAHYDROXYBIPHENYL DERIVATIVES | UNIV NORTH CAROLINA (US) | 1999-12-15 | — | — | EP | disclosed |
| EP-0837677-A1 | BROMINATED HEXAHYDROXYBIPHENYL DERIVATIVES | UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1998-04-29 | — | — | EP | disclosed |
| US-5612341-A | BIS-BENZODIOXOLE COMPOUNDS, TREATMENT OF HIV, VIRICIDES | BIOTECH RESEARCH LABORATORIES (US) | 1997-03-18 | — | — | US | disclosed |
| WO-1996040111-A1 | BROMINATED HEXAHYDROXYBIPHENYL DERIVATIVES | THE UNIVERSITY OF NORTH CAROLINA AT CHAPEL HILL (US) | 1996-12-19 | — | — | WO | disclosed |