Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 1/20 | 0.59 |
| ▸ | HCAR1 | Q9BXC0 | 1/20 | 0.50 |
| ▸ | PI4KA | P42356 | 1/20 | 0.44 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.44 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.44 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.44 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | JAK3 | P52333 | 1/20 | 0.44 |
| ▸ | MKNK1 | Q9BUB5 | 3/20 | 0.40 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CASP1 | P29466 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2186557 | 0.83 | HCAR1 (0.56) | FGFR1HCAR1PI4KAPI4K2BPI4K2A | |
| SCHEMBL30955935 | 0.83 | HCAR1 (0.56) | FGFR1HCAR1PI4KAPI4K2BPI4K2A | |
| SCHEMBL6667117 | 0.80 | FGFR1 (0.56) | FGFR1HCAR1TGFBR1JAK2JAK3 | |
| SCHEMBL22015957 | 0.78 | FGFR1 (0.50) | FGFR1TGFBR1JAK2JAK3MKNK1 | |
| SCHEMBL29240138 | 0.77 | PI4KA (0.57) | FGFR1HCAR1PI4KAPI4K2BPI4K2A | |
| SCHEMBL19320196 | 0.75 | HCAR1 (0.49) | FGFR1HCAR1PI4KAPI4K2BPI4K2A | |
| SCHEMBL6664412 | 0.75 | ALDH1A1 (0.50) | FGFR1HCAR1MAPK1ALDH1A1MAPT | |
| SCHEMBL10644638 | 0.74 | FGFR1 (1.00) | FGFR1MAPK1ALDH1A1MAPTRAB9A | |
| SCHEMBL16035814 | 0.73 | FGFR1 (0.67) | FGFR1TGFBR1JAK2JAK3MKNK1 | |
| SCHEMBL8561860 | 0.72 | NPC1 (0.39) | FGFR1NPC1MAPK1ATMALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0821675-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1998-02-04 | — | — | EP | disclosed |
| WO-1996033176-A1 | NOVEL HYDROXAMIC ACID AND AMINO-CARBOXYLATE COMPOUNDS AS METALLOPROTEASE AND TNF INHIBITORS | THE DU PONT MERCK PHARMACEUTICAL COMPANY (US) | 1996-10-24 | — | — | WO | disclosed |