Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | UTS2R | Q9UKP6 | 7/20 | 0.44 |
| ▸ | DRD2 | P14416 | 1/20 | 0.38 |
| ▸ | DRD3 | P35462 | 1/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 3/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.36 |
| ▸ | CCR4 | P51679 | 1/20 | 0.36 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.35 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 2/20 | 0.35 |
| ▸ | MAOB | P27338 | 2/20 | 0.35 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.35 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.34 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | CFTR | P13569 | 1/20 | 0.34 |
| ▸ | UBE2I | P63279 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8562141 | 0.92 | OPRK1 (0.44) | UTS2RDRD2DRD3OPRK1CYP3A4 | |
| SCHEMBL8561099 | 0.89 | THRB (0.38) | UTS2RMAPK1HPGDALOX15HTT | |
| SCHEMBL8564538 | 0.89 | UTS2R (0.38) | UTS2ROPRK1CYP3A4CYP2D6HRH3 | |
| SCHEMBL8563885 | 0.88 | OPRK1 (0.44) | UTS2RDRD2DRD3OPRK1CYP3A4 | |
| SCHEMBL8563085 | 0.87 | OPRK1 (0.44) | UTS2RDRD2DRD3OPRK1HRH3 | |
| SCHEMBL8557546 | 0.87 | CNR1 (0.43) | MAPK1 | |
| SCHEMBL8560299 | 0.85 | UTS2R (0.41) | UTS2ROPRK1CYP3A4CYP2D6KDM4C | |
| SCHEMBL8564526 | 0.84 | OPRK1 (0.43) | UTS2RDRD2DRD3OPRK1CYP3A4 | |
| SCHEMBL8565280 | 0.84 | UTS2R (0.42) | UTS2ROPRK1KDM4CHRH3 | |
| SCHEMBL8560977 | 0.83 | UTS2R (0.37) | UTS2ROPRK1CYP3A4CYP2D6HRH3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5756730-A | Process for preparing analgesic compounds | SANKYO COMPANY, LIMITED (JP) | 1998-05-26 | — | — | US | disclosed |
| US-5656758-A | AMIDATION OF AN AMINE-CONTAINING THIOMORPHOLINE OR PIPERAZINE COMPOUND | SANKYO COMPANY, LIMITED (JP) | 1997-08-12 | — | — | US | disclosed |
| US-5512567-A | KAPPA-RECEPTOR AGONISTS | SANKYO COMPANY, LIMITED (JP) | 1996-04-30 | — | — | US | disclosed |
| US-5270327-A | Piperidine derivatives | SANKYO COMPANY, LIMITED (JP) | 1993-12-14 | — | — | US | disclosed |
| EP-0356247-B1 | ANALGESIC CARBOXYLIC ACID AMIDE DERIVATIVES | Sankyo Company Limited (JP) | 1993-03-17 | — | — | EP | disclosed |
| US-5021413-A | Analgesic thiomorpholins their preparation, and pharmaceutical compositions containing them | SANKYO COMPANY LIMITED (JP) | 1991-06-04 | — | — | US | disclosed |
| EP-0356247-A1 | Analgesic carboxylic acid amide derivatives | Sankyo Company Limited (JP) | 1990-02-28 | — | — | EP | disclosed |