Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 3/20 | 0.46 |
| ▸ | PLA2G2D | Q9UNK4 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | MAOB | P27338 | 1/20 | 0.39 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.39 |
| ▸ | PTGES | O14684 | 2/20 | 0.38 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.38 |
| ▸ | PPARG | P37231 | 2/20 | 0.38 |
| ▸ | PSEN1 | P49768 | 2/20 | 0.38 |
| ▸ | CYSLTR2 | Q9NS75 | 1/20 | 0.37 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9074308 | 0.92 | NR1H4 (0.46) | NR1H4PLA2G2DTSHRMAOBGGPS1 | |
| SCHEMBL8995673 | 0.89 | NR1H4 (0.48) | NR1H4PLA2G2DMAOBCYSLTR2CYSLTR1 | |
| SCHEMBL6755904 | 0.87 | NR1H4 (0.46) | NR1H4MAOBALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL8566089 | 0.87 | MAOB (0.50) | NR1H4PLA2G2DMAOBCYSLTR2CYSLTR1 | |
| SCHEMBL8566430 | 0.84 | NR1H4 (0.51) | NR1H4 | |
| SCHEMBL8568129 | 0.80 | NR1H4 (0.47) | NR1H4 | |
| SCHEMBL8651806 | 0.79 | NR1H4 (0.54) | NR1H4GGPS1 | |
| SCHEMBL6762437 | 0.79 | MAOB (0.47) | MAOB | |
| SCHEMBL6894310 | 0.79 | NR1H4 (0.44) | NR1H4MAOBALOX5CYSLTR2CYSLTR1 | |
| SCHEMBL4472796 | 0.78 | ALOX5 (0.49) | MAOBALOX5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0544488-B1 | Substituted phenyl phenol leukotriene antagonists | LILLY CO ELI (US) | 1998-03-11 | — | — | EP | disclosed |
| WO-1996036347-A1 | USE OF LEUKOTRIENE ANTAGONISTS FOR ALZHEIMER'S DISEASE | ELI LILLY AND COMPANY (US) | 1996-11-21 | — | — | WO | disclosed |
| EP-0743064-A1 | Leukotriene antagonists for use in the treatment or prevention of alzheimer's disease | ELI LILLY AND COMPANY (US) | 1996-11-20 | — | — | EP | disclosed |
| US-5462954-A | Antiinflammatory, antiallergens; treating asthma | ELI LILLY AND COMPANY (US) | 1995-10-31 | — | — | US | disclosed |
| EP-0544488-A2 | Substituted phenyl phenol leukotriene antagonists | ELI LILLY AND COMPANY (US) | 1993-06-02 | — | — | EP | disclosed |